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• W2006244485 abstract "Primary objective: To study the predictive capacity of early S100β samples for long-term outcome prediction after severe TBI.Methods and procedures: Eighty-seven patients with severe TBI were studied. Clinical and CT scan were taken at admission. S100β concentration was quantified at admission and 24, 48 and 72 hours post-TBI (days 0, 1, 2 and 3). Outcome was assessed 12 months after discharge using Glasgow Outcome Score (GOS).Results: Significant negative correlations were found between 1-year GOS and S100β concentrations on days 1–3, but not on day 0. Deceased patients showed higher S100β concentration than survivors on days 1–3. Good (GOS = 4–5) vs poor outcome (GOS = 1–3) differed significantly on day 3. Death outcome was independently predicted by day 2 (>2.37 µg l−1), day 3 (>1.41 µg l−1) samples and absence of pupillary reaction. Poor outcome was predicted independently only by pupillary reaction and the 72-hour sample (>1.1 µg l−1), but this predictive model was less satisfactory than the predictive model for death.Conclusions: A temporal profile of S100β release from admission to 72 hours post-TBI is strongly recommended for use in identifying patients at risk of developing a worse outcome. The S100β protein might be an early biomarker for predicting long-term outcome in patients with acute severe TBI." @default.
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• W2006244485 date "2010-03-30" @default.
• W2006244485 modified "2023-10-17" @default.
• W2006244485 title "The prognostic value of the temporal course of S100<i>β</i>protein in post-acute severe brain injury: A prospective and observational study" @default.
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• W2006244485 doi "https://doi.org/10.3109/02699051003652823" @default.
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