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• W2006246032 abstract "This study assessed in vitro inhibition of plasma and brain cholinesterases (ChE) by the organophosphate insecticides chlorpyrifos and dichlorvos in chicks at ages of 2, 10, 20 and 30 days. Plasma samples and whole-brain homogenates of each age group were pooled and ChE activity was determined by an electrometric method with or without the organophosphate (0.5 and 1.0 µM). ChE inhibitions were the highest in 2- and 10-day-old chicks (20–83%), followed by 5–73% inhibitions at ages of 20 and 30 days. Cholrpyrifos decreased plasma ChE activity only at the ages of 2 and 10 days by 21–75%. Dichlorvos decreased plasma ChE activity at all the ages tested (2–30 days) by 39–83%. The highest percentage of plasma ChE inhibition by chlorpyrifos and dichlorvos was in 2-day-old chicks. In the brain homogenate, chlorpyrifos decreased the ChE activity between ages 2 and 20 days by 20–62%. The highest percentage of brain ChE inhibition occurred at the age of 10 days and the least was at 20 and 30 days. Dichlorvos decreased brain ChE activity between ages 2 and 20 days by 24–74%. At the age of 30 days, only the higher concentration of dichlorvos (1 µM) decreased brain ChE activity by 27%. The data suggest an age-related differential in vitro inhibition of plasma and brain ChE s in chicks. In vitro ChE inhibition, though it does not exclude interfering factors, could be useful for initial screening of the inhibitory actions of organophosphate insecticides in chickens." @default.
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• W2006246032 date "2014-01-17" @default.
• W2006246032 modified "2023-09-27" @default.
• W2006246032 title "<i>In vitro</i>inhibition of plasma and brain cholinesterases of growing chicks by chlorpyrifos and dichlorvos" @default.
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• W2006246032 doi "https://doi.org/10.1080/09712119.2013.875912" @default.
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