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• W2006249715 abstract "HomeHypertensionVol. 3, No. 2Renal prostaglandin excretion and metabolism in male and female New Zealand normotensive and genetically hypertensive rats. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBRenal prostaglandin excretion and metabolism in male and female New Zealand normotensive and genetically hypertensive rats. P G Baer and L M Cagen P G BaerP G Baer Search for more papers by this author and L M CagenL M Cagen Search for more papers by this author Originally published1 Mar 1981https://doi.org/10.1161/01.HYP.3.2.257Hypertension. 1981;3:257–261AbstractReduced renal 15-hydroxyprostaglandin dehydrogenase (PGDH) activity has been proposed as a cause, subsequent to elevation of intrarenal prostaglandin (PG) E2 levels, of the development or maintenance of high blood pressure (BP) in the New Zealand genetically hypertensive (NZGH) rat. To test this hypothesis, PGDH activity in homogenates of kidneys and lungs and in urine concentration and excretion of PGE2 were determined in male and female NZGH and normotensive control (NZNR) rats. Lung PGDH activities of the four groups were similar. Renal PGDH activity was 50% lower for the male NZGH than for the male NZNR, but for the female rats no difference in renal PGDH activity was found between NZGH and NZNR. In addition, there was a large sex-related difference in renal PGDH activities, values for the female rats being only 5% to 10% of the values for males. Urine PGE2 concentration and excretion were two to five times greater for the female rats than for the males, but did not differ between male NZGH and male NZNR. From these observations, it appears that neither renal PGDH activity nor urine PGE2 levels is associated with hypertension in the New Zealand genetically hypertensive strain of rats. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Flower R (2015) On the Eicosanoid Trail with John Vane and Jack McGiff: 1974–1976. A personal reminiscence, Prostaglandins & Other Lipid Mediators, 10.1016/j.prostaglandins.2015.03.001, 120, (3-8), Online publication date: 1-Jul-2015. Herrera V and Ruiz-Opazo N (2008) Rat as a model system for hypertension drug discovery, Drug Discovery Today: Disease Models, 10.1016/j.ddmod.2009.03.003, 5:3, (179-184), Online publication date: 1-Sep-2008. Nasjletti A and Baer P (1988) Prostanoids in clinical and experimental hypertension Eicosanoids in the Cardiovascular and Renal Systems, 10.1007/978-94-009-1285-4_7, (159-175), . Cagen L and Baer P (1987) Effects of gonadectomy and steroid treatment on renal prostaglandin 9-ketoreductase activity in the rat, Life Sciences, 10.1016/0024-3205(87)90257-8, 40:1, (95-100), Online publication date: 1-Jan-1987. Wong R, Boedecker B and Maydonovitch C (1986) Sex differences in gastric mucosal protection after 16, 16-dimethyl PGE2 and lithium chloride, Prostaglandins, 10.1016/0090-6980(86)90037-7, 32:4, (555-561), Online publication date: 1-Oct-1986. Nakanishi T, Shiigai T and Endou H (2009) Localization and Properties of Nad-Dependent 15 Hydroxyprostaglandin Dehydrogenase Activity in Spontaneously Hypertensive Rat Kidney, Clinical and Experimental Hypertension. Part A: Theory and Practice, 10.3109/10641968609074766, 8:1, (91-112), Online publication date: 1-Jan-1986. Cagen L, Killmar J, Warren W and Baer P (1985) Estradiol is responsible for reduced renal prostaglandin dehydrogenase activity in female rats, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 10.1016/0005-2760(85)90093-1, 833:3, (372-378), Online publication date: 1-Mar-1985. Speziale E, Speziale N, Lugo S and Gimeno M (1984) Rat renal medulla possess high capacity to catabolize prostaglandins, Biochemical and Biophysical Research Communications, 10.1016/0006-291X(84)90917-3, 124:1, (69-74), Online publication date: 1-Oct-1984. Sullivan J and McGiff J (1984) Kallikrein-Kinin- und Prostaglandin-Systeme bei Hypertonie Arterielle Hypertonie, 10.1007/978-3-662-00760-0_15, (254-280), . Powers C, Baer P and Nasjletti A (1984) Reduced glandular kallikrein-like activity in the anterior pituitary of the new zealand genetically hypertensive rat, Biochemical and Biophysical Research Communications, 10.1016/S0006-291X(84)80305-8, 119:2, (689-693), Online publication date: 1-Mar-1984. Dunn M (1983) Renal Prostaglandins Contemporary Nephrology, 10.1007/978-1-4615-6722-6_4, (145-192), . Cagen L and Kauker M (1983) Metabolism of intratubular prostaglandin E2 in the rat kidney, Biochemical Pharmacology, 10.1016/0006-2952(83)90322-2, 32:23, (3665-3668), Online publication date: 1-Dec-1983. Benzoni D, Vincent M and Sassard J (1982) Urinary prostaglandins in the Lyon strains of hypertensive, normotensive, and low blood pressure rats., Hypertension, 4:2, (325-328), Online publication date: 1-Mar-1982.Diz D, Nasjletti A and Baer P (1982) Renal denervation at weaning retards development of hypertension in New Zealand genetically hypertensive rats., Hypertension, 4:3, (361-368), Online publication date: 1-May-1982. March 1981Vol 3, Issue 2 Article InformationMetrics Copyright © 1981 by American Heart Associationhttps://doi.org/10.1161/01.HYP.3.2.257PMID: 7216380 Originally publishedMarch 1, 1981 PDF download Advertisement" @default.
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