Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006258052> ?p ?o ?g. }
- W2006258052 endingPage "1742" @default.
- W2006258052 startingPage "1742" @default.
- W2006258052 abstract "Induction of the cytochrome P4501A (CYP1A) enzyme system in fish is a common biomarker of exposure to aromatic hydrocarbons. Induction of CYP1A can be measured at a number of steps in the transcription—translation—functional protein pathway using a variety of techniques. The present study examined the range of these measurements from 94 published papers in an attempt to examine the statistical characteristics of each method. Cytochrome P4501A induction, as measured by catalytic ethoxyresorufin-O-deethylase (EROD) activity, protein levels (enzyme-linked immunosorbent assay, Western blot analysis, and immunohistochemistry), and mRNA levels (Northern blot analysis and reverse transcription—polymerase chain reaction), was analyzed. When possible, the variance structure, effect size determination, and dose—response modeling of each method of measurement in the laboratory and field were examined. Conclusions from this analysis include: 1) Because of interlaboratory and interspecies variability, general end-point determinations will need to be defined in terms of the statistically detectable fold-change of measurements relative to control or reference values, and 2) fold-change in EROD activity provides the most robust measure of the dose responsiveness of aromatic hydrocarbons within specific chemical classes (e.g., polycyclic aromatic hydrocarbons). The relationship between the ability to measure statistical differences in induction level and the biological significance of those measurements has yet to be defined. To utilize these biomarkers in a risk assessment context, this relationship must be addressed at the scientific and management levels." @default.
- W2006258052 created "2016-06-24" @default.
- W2006258052 creator A5016227830 @default.
- W2006258052 creator A5078463294 @default.
- W2006258052 date "2007-01-01" @default.
- W2006258052 modified "2023-10-11" @default.
- W2006258052 title "STATISTICAL ANALYSIS OF CYTOCHROME P4501A BIOMARKER MEASUREMENTS IN FISH" @default.
- W2006258052 cites W1825797403 @default.
- W2006258052 cites W1965037767 @default.
- W2006258052 cites W1966225100 @default.
- W2006258052 cites W1967548464 @default.
- W2006258052 cites W1969257731 @default.
- W2006258052 cites W1969724402 @default.
- W2006258052 cites W1972206206 @default.
- W2006258052 cites W1973101071 @default.
- W2006258052 cites W1975334595 @default.
- W2006258052 cites W1978468806 @default.
- W2006258052 cites W1979149120 @default.
- W2006258052 cites W1979454761 @default.
- W2006258052 cites W1980440165 @default.
- W2006258052 cites W1981972410 @default.
- W2006258052 cites W1982958533 @default.
- W2006258052 cites W1986301574 @default.
- W2006258052 cites W1989007576 @default.
- W2006258052 cites W1989978756 @default.
- W2006258052 cites W1990131329 @default.
- W2006258052 cites W1991410895 @default.
- W2006258052 cites W1991970934 @default.
- W2006258052 cites W1996606835 @default.
- W2006258052 cites W1997551470 @default.
- W2006258052 cites W2002421635 @default.
- W2006258052 cites W2003710683 @default.
- W2006258052 cites W2005076557 @default.
- W2006258052 cites W2006997251 @default.
- W2006258052 cites W2006998778 @default.
- W2006258052 cites W2007014190 @default.
- W2006258052 cites W2007463085 @default.
- W2006258052 cites W2007470005 @default.
- W2006258052 cites W2007656494 @default.
- W2006258052 cites W2007787899 @default.
- W2006258052 cites W2009489349 @default.
- W2006258052 cites W2010031741 @default.
- W2006258052 cites W2014438558 @default.
- W2006258052 cites W2015756087 @default.
- W2006258052 cites W2016183163 @default.
- W2006258052 cites W2016466887 @default.
- W2006258052 cites W2020597160 @default.
- W2006258052 cites W2022323857 @default.
- W2006258052 cites W2022818049 @default.
- W2006258052 cites W2023887872 @default.
- W2006258052 cites W2023998996 @default.
- W2006258052 cites W2024493657 @default.
- W2006258052 cites W2024502335 @default.
- W2006258052 cites W2024584876 @default.
- W2006258052 cites W2024958453 @default.
- W2006258052 cites W2025680729 @default.
- W2006258052 cites W2028913197 @default.
- W2006258052 cites W2030351645 @default.
- W2006258052 cites W2030607204 @default.
- W2006258052 cites W2031034655 @default.
- W2006258052 cites W2031374445 @default.
- W2006258052 cites W2034176641 @default.
- W2006258052 cites W2035472270 @default.
- W2006258052 cites W2036982876 @default.
- W2006258052 cites W2037080785 @default.
- W2006258052 cites W2037374032 @default.
- W2006258052 cites W2037836603 @default.
- W2006258052 cites W2038543321 @default.
- W2006258052 cites W2038732400 @default.
- W2006258052 cites W2039083386 @default.
- W2006258052 cites W2039920156 @default.
- W2006258052 cites W2041194643 @default.
- W2006258052 cites W2042199991 @default.
- W2006258052 cites W2043261531 @default.
- W2006258052 cites W2044947556 @default.
- W2006258052 cites W2048536830 @default.
- W2006258052 cites W2049604151 @default.
- W2006258052 cites W2054033965 @default.
- W2006258052 cites W2054397123 @default.
- W2006258052 cites W2055972970 @default.
- W2006258052 cites W2055977125 @default.
- W2006258052 cites W2057586755 @default.
- W2006258052 cites W2059727521 @default.
- W2006258052 cites W2060243273 @default.
- W2006258052 cites W2060852637 @default.
- W2006258052 cites W2064970547 @default.
- W2006258052 cites W2066000066 @default.
- W2006258052 cites W2066439231 @default.
- W2006258052 cites W2066925111 @default.
- W2006258052 cites W2068637635 @default.
- W2006258052 cites W2069046368 @default.
- W2006258052 cites W2074544226 @default.
- W2006258052 cites W2075749183 @default.
- W2006258052 cites W2077693699 @default.
- W2006258052 cites W2078493901 @default.
- W2006258052 cites W2083299186 @default.
- W2006258052 cites W2084284892 @default.
- W2006258052 cites W2085894854 @default.