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- W2006261800 abstract "The daily oral administration of dibutyl phthalate (DBP) at 2000 mg/kg for 4 days to young male rats was found to produce testicular injury and loss in organ weight. Additionally, it was found that DBP treatment adversely affected zinc metabolism. The urinary excretion of zinc was increased and the zinc content in the testes was markedly decreased. Moreover; the turnover rate of this element in testicular tissue was substantially enhanced. DBP treatment did not significantly alter the zinc concentrations in the kidney and liver. Investigations using n-butanol, o-phthalic acid, and monobutyl phthalate (MBP), the major metabolite of DBP, showed that testicular effects were reproducible by MBP. Coadministration of zinc was found to afford a substantial measure of protection against testicular damage produced by DBP." @default.
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- W2006261800 title "Studies on dibutyl phthalate-induced testicular atrophy in the rat: Effect on zinc metabolism" @default.
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- W2006261800 doi "https://doi.org/10.1016/s0041-008x(77)80014-8" @default.
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