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• W2006266799 abstract "The evolutionary preservation of reactive oxygen species in innate immunity underscores the important roles these constituents play in immune cell activity and as signaling intermediates. In an effort to exploit these pathways to achieve control of aberrant immune activation we demonstrate that modulation of redox status suppresses cell proliferation and production of IL-2, IFN-γ, TNF-α, and IL-17 in two robust CD8 T-cell-dependent in vitro mouse models: (1) response to alloantigen in an mixed leukocyte reaction and (2) CD8 T cell receptor transgenic OT-1 response to cognate peptide (SIINFEKL). To correlate these findings with cytotoxic lymphocyte (CTL) function we performed cytotoxicity assays and found that redox modulation diminishes the ability of alloantigen-specific and antigen-specific OT-1 CTLs to kill their corresponding antigen-expressing target cells. To further examine the mechanisms of redox-mediated repression of CTL target cell lysis, we analyzed the expression of the effector molecules IFN-γ, perforin, and granzyme B and the degranulation marker CD107a (LAMP-1). In both models, redox modulation reduced the expression of these effector components by at least fivefold. These results demonstrate that redox modulation quells the CD8 T cell response to alloantigen and the T cell receptor transgenic CD8 T cell response to its cognate antigen by inhibiting proliferation, proinflammatory cytokine synthesis, and CTL effector mechanisms." @default.
• W2006266799 created "2016-06-24" @default.
• W2006266799 creator A5026708404 @default.
• W2006266799 creator A5061572806 @default.
• W2006266799 creator A5064167863 @default.
• W2006266799 date "2008-11-01" @default.
• W2006266799 modified "2023-09-26" @default.
• W2006266799 title "Redox modulation inhibits CD8 T cell effector function" @default.
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• W2006266799 cites W1553271826 @default.
• W2006266799 cites W1595539869 @default.
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• W2006266799 doi "https://doi.org/10.1016/j.freeradbiomed.2008.08.023" @default.
• W2006266799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18805480" @default.
• W2006266799 hasPublicationYear "2008" @default.
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