FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006269123> ?p ?o ?g. }

• W2006269123 endingPage "e131" @default.
• W2006269123 startingPage "e123" @default.
• W2006269123 abstract "The aim of this study is to clarify the efficacy of proteasome inhibitor bortezomib to multidrug resistant (MDR) acute leukemia cells. We observed the effects of bortezomib on a P-glycoprotein (P-gp) positive leukemia line K562/A02. The results showed that bortezomib has significant effects on P-gp positive K562/A02 cells including cytotoxicity (48 h IC50: 171.36 nm), induction of apoptosis (31.71 ± 1.07% apoptotic cells after 24 h treatment at 100 nm), and inhibition of proteasome chymotrypsin-like activity (relative activity to untreated controls: 20.07 ± 0.66% at 24 h with 10 nm bortezomib). These effects were lower than those observed in K562 cells (IC50, percentage of apoptotic cells, relative chymotrypsin-like activity to untreated controls were 56.28 nm, 77.95 ± 0.35%, 5.35 ± 2.05% after the same treatments, respectively). No synergy between daunorubicin and bortezomib was shown in the killing of K562/A02 cells (synergistic ratios were <1). P-gp expression levels did not decrease in K562/A02 cells after bortezomib treatment. Pretreatment with bortezomib does not improve the intracellular anthracycline concentration in K562/A02 cells. Bortezomib shows a promising effect for the treatment of refractory/relapsed leukemia, but it does not improve the effect of anthracycline to MDR leukemia cells." @default.
• W2006269123 created "2016-06-24" @default.
• W2006269123 creator A5000544793 @default.
• W2006269123 creator A5020792862 @default.
• W2006269123 creator A5040227645 @default.
• W2006269123 creator A5062370040 @default.
• W2006269123 creator A5064562354 @default.
• W2006269123 creator A5070264667 @default.
• W2006269123 creator A5077582367 @default.
• W2006269123 creator A5080792009 @default.
• W2006269123 creator A5087161790 @default.
• W2006269123 date "2010-02-01" @default.
• W2006269123 modified "2023-09-25" @default.
• W2006269123 title "The effects of proteasome inhibitor bortezomib on a P-gp positive leukemia cell line K562/A02" @default.
• W2006269123 cites W1837700344 @default.
• W2006269123 cites W1935443268 @default.
• W2006269123 cites W1967133615 @default.
• W2006269123 cites W2009656063 @default.
• W2006269123 cites W2024846074 @default.
• W2006269123 cites W2032804703 @default.
• W2006269123 cites W2041351111 @default.
• W2006269123 cites W2041622856 @default.
• W2006269123 cites W2057292793 @default.
• W2006269123 cites W2067530043 @default.
• W2006269123 cites W2075165800 @default.
• W2006269123 cites W2088312168 @default.
• W2006269123 cites W2118886727 @default.
• W2006269123 cites W2119680582 @default.
• W2006269123 cites W2122597368 @default.
• W2006269123 cites W2124560610 @default.
• W2006269123 cites W2166043738 @default.
• W2006269123 cites W2169249834 @default.
• W2006269123 cites W37351408 @default.
• W2006269123 doi "https://doi.org/10.1111/j.1751-553x.2009.01145.x" @default.
• W2006269123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19254348" @default.
• W2006269123 hasPublicationYear "2010" @default.
• W2006269123 type Work @default.
• W2006269123 sameAs 2006269123 @default.
• W2006269123 citedByCount "21" @default.
• W2006269123 countsByYear W20062691232012 @default.
• W2006269123 countsByYear W20062691232013 @default.
• W2006269123 countsByYear W20062691232014 @default.
• W2006269123 countsByYear W20062691232015 @default.
• W2006269123 countsByYear W20062691232016 @default.
• W2006269123 countsByYear W20062691232017 @default.
• W2006269123 countsByYear W20062691232019 @default.
• W2006269123 countsByYear W20062691232022 @default.
• W2006269123 crossrefType "journal-article" @default.
• W2006269123 hasAuthorship W2006269123A5000544793 @default.
• W2006269123 hasAuthorship W2006269123A5020792862 @default.
• W2006269123 hasAuthorship W2006269123A5040227645 @default.
• W2006269123 hasAuthorship W2006269123A5062370040 @default.
• W2006269123 hasAuthorship W2006269123A5064562354 @default.
• W2006269123 hasAuthorship W2006269123A5070264667 @default.
• W2006269123 hasAuthorship W2006269123A5077582367 @default.
• W2006269123 hasAuthorship W2006269123A5080792009 @default.
• W2006269123 hasAuthorship W2006269123A5087161790 @default.
• W2006269123 hasConcept C126322002 @default.
• W2006269123 hasConcept C171122931 @default.
• W2006269123 hasConcept C185592680 @default.
• W2006269123 hasConcept C190283241 @default.
• W2006269123 hasConcept C2776364478 @default.
• W2006269123 hasConcept C2777478702 @default.
• W2006269123 hasConcept C2778367456 @default.
• W2006269123 hasConcept C2778461978 @default.
• W2006269123 hasConcept C2781021840 @default.
• W2006269123 hasConcept C502942594 @default.
• W2006269123 hasConcept C55493867 @default.
• W2006269123 hasConcept C71924100 @default.
• W2006269123 hasConcept C98274493 @default.
• W2006269123 hasConceptScore W2006269123C126322002 @default.
• W2006269123 hasConceptScore W2006269123C171122931 @default.
• W2006269123 hasConceptScore W2006269123C185592680 @default.
• W2006269123 hasConceptScore W2006269123C190283241 @default.
• W2006269123 hasConceptScore W2006269123C2776364478 @default.
• W2006269123 hasConceptScore W2006269123C2777478702 @default.
• W2006269123 hasConceptScore W2006269123C2778367456 @default.
• W2006269123 hasConceptScore W2006269123C2778461978 @default.
• W2006269123 hasConceptScore W2006269123C2781021840 @default.
• W2006269123 hasConceptScore W2006269123C502942594 @default.
• W2006269123 hasConceptScore W2006269123C55493867 @default.
• W2006269123 hasConceptScore W2006269123C71924100 @default.
• W2006269123 hasConceptScore W2006269123C98274493 @default.
• W2006269123 hasIssue "1p1" @default.
• W2006269123 hasLocation W20062691231 @default.
• W2006269123 hasLocation W20062691232 @default.
• W2006269123 hasOpenAccess W2006269123 @default.
• W2006269123 hasPrimaryLocation W20062691231 @default.
• W2006269123 hasRelatedWork W1930641740 @default.
• W2006269123 hasRelatedWork W2006269123 @default.
• W2006269123 hasRelatedWork W2033803187 @default.
• W2006269123 hasRelatedWork W2243925837 @default.
• W2006269123 hasRelatedWork W2356578462 @default.
• W2006269123 hasRelatedWork W2378772640 @default.
• W2006269123 hasRelatedWork W2385410559 @default.
• W2006269123 hasRelatedWork W2564561218 @default.
• W2006269123 hasRelatedWork W3145501416 @default.
• W2006269123 hasRelatedWork W2189359689 @default.

• next