FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006272024> ?p ?o ?g. }

• W2006272024 endingPage "3401" @default.
• W2006272024 startingPage "3395" @default.
• W2006272024 abstract "To determine whether leptin has insulin sensitizing effects in normal rodents, we measured plasma glucose and insulin concentrations in male Sprague-Dawley rats treated with leptin or vehicle by continuous s.c. infusion for 48 h. In additional experiments, we examined the acute effect of i.v. leptin upon insulin sensitivity under conditions of clamped glycemia. Subcutaneous leptin was administered at 10.0 and 1.0 microg/h. To avoid confounding effects of differences in food intake, both leptin- and vehicle-treated rats were fasted during the 48-h period of infusion. Infusion of leptin, 10 microg/h, significantly reduced both plasma glucose and insulin. Leptin, 1.0 microg/h, also decreased plasma glucose and insulin, although the effects on insulin did not achieve statistical significance. Leptin at either dose did not alter body weight or epididymal fat mass compared with vehicle treated controls. Leptin, 10 microg/h, decreased circulating insulin-like growth factor-1 levels. No differences in GLUT-4 content in either in brown or epididymal fat were observed as a result of leptin-treatment. Leptin, 10 microg/h, significantly decreased urine osmolality, increased water intake, and reduced renal potassium excretion compared with vehicle-infused rats. In additional rats, we measured the acute effect of i.v. leptin on insulin sensitivity determined as whole body glucose utilization during hyperinsulinemic glucose clamps performed at glucose targets of 60 and 90 mg/100 ml. Glucose utilization was increased by 29% during the last 135 min of glycemia clamped at 60 mg/100 ml (P < 0.05) and by 30% during the last 135 min of glycemia clamped at 90 mg/dl (P < 0.01) in rats infused with leptin compared with vehicle. In summary, leptin increased insulin sensitivity in normal rats both under fasting conditions and in the presence of hyperinsulinemia at clamped glucose. These effects did not appear dependent on altered body weight. Leptin also altered salt and water metabolism under fasting conditions resulting in increased water intake and more dilute urine." @default.
• W2006272024 created "2016-06-24" @default.
• W2006272024 creator A5031453521 @default.
• W2006272024 creator A5032808557 @default.
• W2006272024 creator A5057697054 @default.
• W2006272024 creator A5068748727 @default.
• W2006272024 creator A5070617034 @default.
• W2006272024 date "1997-08-01" @default.
• W2006272024 modified "2023-10-13" @default.
• W2006272024 title "Effects of Leptin on Insulin Sensitivity in Normal Rats*" @default.
• W2006272024 cites W146700098 @default.
• W2006272024 cites W1793329854 @default.
• W2006272024 cites W1965482152 @default.
• W2006272024 cites W1971060217 @default.
• W2006272024 cites W1971630008 @default.
• W2006272024 cites W1972970479 @default.
• W2006272024 cites W2004497291 @default.
• W2006272024 cites W2007153731 @default.
• W2006272024 cites W2007867899 @default.
• W2006272024 cites W2012853250 @default.
• W2006272024 cites W2013583119 @default.
• W2006272024 cites W2014093920 @default.
• W2006272024 cites W2020971663 @default.
• W2006272024 cites W2025846514 @default.
• W2006272024 cites W2027360957 @default.
• W2006272024 cites W2028627182 @default.
• W2006272024 cites W2043982697 @default.
• W2006272024 cites W2051559850 @default.
• W2006272024 cites W2055956383 @default.
• W2006272024 cites W2060682066 @default.
• W2006272024 cites W2062001615 @default.
• W2006272024 cites W2074745748 @default.
• W2006272024 cites W2078745862 @default.
• W2006272024 cites W2087015690 @default.
• W2006272024 cites W2091087465 @default.
• W2006272024 cites W2096660073 @default.
• W2006272024 cites W2103240729 @default.
• W2006272024 cites W2111232488 @default.
• W2006272024 cites W2154768074 @default.
• W2006272024 cites W2334337188 @default.
• W2006272024 doi "https://doi.org/10.1210/endo.138.8.5327" @default.
• W2006272024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9231793" @default.
• W2006272024 hasPublicationYear "1997" @default.
• W2006272024 type Work @default.
• W2006272024 sameAs 2006272024 @default.
• W2006272024 citedByCount "204" @default.
• W2006272024 countsByYear W20062720242012 @default.
• W2006272024 countsByYear W20062720242013 @default.
• W2006272024 countsByYear W20062720242014 @default.
• W2006272024 countsByYear W20062720242015 @default.
• W2006272024 countsByYear W20062720242016 @default.
• W2006272024 countsByYear W20062720242017 @default.
• W2006272024 countsByYear W20062720242018 @default.
• W2006272024 countsByYear W20062720242019 @default.
• W2006272024 countsByYear W20062720242020 @default.
• W2006272024 countsByYear W20062720242021 @default.
• W2006272024 countsByYear W20062720242022 @default.
• W2006272024 crossrefType "journal-article" @default.
• W2006272024 hasAuthorship W2006272024A5031453521 @default.
• W2006272024 hasAuthorship W2006272024A5032808557 @default.
• W2006272024 hasAuthorship W2006272024A5057697054 @default.
• W2006272024 hasAuthorship W2006272024A5068748727 @default.
• W2006272024 hasAuthorship W2006272024A5070617034 @default.
• W2006272024 hasBestOaLocation W20062720241 @default.
• W2006272024 hasConcept C126322002 @default.
• W2006272024 hasConcept C134018914 @default.
• W2006272024 hasConcept C185592680 @default.
• W2006272024 hasConcept C2777391703 @default.
• W2006272024 hasConcept C2779306644 @default.
• W2006272024 hasConcept C2780352109 @default.
• W2006272024 hasConcept C2780613262 @default.
• W2006272024 hasConcept C511355011 @default.
• W2006272024 hasConcept C71924100 @default.
• W2006272024 hasConceptScore W2006272024C126322002 @default.
• W2006272024 hasConceptScore W2006272024C134018914 @default.
• W2006272024 hasConceptScore W2006272024C185592680 @default.
• W2006272024 hasConceptScore W2006272024C2777391703 @default.
• W2006272024 hasConceptScore W2006272024C2779306644 @default.
• W2006272024 hasConceptScore W2006272024C2780352109 @default.
• W2006272024 hasConceptScore W2006272024C2780613262 @default.
• W2006272024 hasConceptScore W2006272024C511355011 @default.
• W2006272024 hasConceptScore W2006272024C71924100 @default.
• W2006272024 hasIssue "8" @default.
• W2006272024 hasLocation W20062720241 @default.
• W2006272024 hasLocation W20062720242 @default.
• W2006272024 hasOpenAccess W2006272024 @default.
• W2006272024 hasPrimaryLocation W20062720241 @default.
• W2006272024 hasRelatedWork W1580329694 @default.
• W2006272024 hasRelatedWork W2040180751 @default.
• W2006272024 hasRelatedWork W2065106131 @default.
• W2006272024 hasRelatedWork W2076336230 @default.
• W2006272024 hasRelatedWork W2095521624 @default.
• W2006272024 hasRelatedWork W2121534565 @default.
• W2006272024 hasRelatedWork W2124070488 @default.
• W2006272024 hasRelatedWork W2165252181 @default.
• W2006272024 hasRelatedWork W2412522302 @default.
• W2006272024 hasRelatedWork W5590367 @default.
• W2006272024 hasVolume "138" @default.

• next