FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006272302> ?p ?o ?g. }

• W2006272302 endingPage "20041" @default.
• W2006272302 startingPage "20036" @default.
• W2006272302 abstract "Meiotic recombination initiates via programmed double-strand breaks (DSBs). We investigate whether, at a given initiation site, DSBs occur independently among the four available chromatids. For a single DSB hot spot, the proportions of nuclei exhibiting zero, one, or two (or more) observable events were defined by tetrad analysis and compared with those predicted by different DSB distribution scenarios. Wild-type patterns are incompatible with independent distribution of DSBs among the four chromatids. In most or all nuclei, DSBs occur one-per-pair of chromatids, presumptively sisters. In many nuclei, only one DSB occurs per four chromatids, confirming the existence of trans inhibition where a DSB on one chromosome interactively inhibits DSB formation on the partner chromosome. Several mutants exhibit only a one-per-pair constraint, a phenotype we propose to imply loss of trans inhibition. Signal transduction kinases Mec1 (ATR) and Tel1 (ATM) exhibit this phenotype and thus could be mediators of this effect. Spreading trans inhibition can explain even spacing of total recombinational interactions and implies that establishment of interhomolog interactions and DSB formation are homeostatic processes. The two types of constraints on DSB formation provide two different safeguards against recombination failure during meiosis." @default.
• W2006272302 created "2016-06-24" @default.
• W2006272302 creator A5017398792 @default.
• W2006272302 creator A5024049281 @default.
• W2006272302 creator A5048444476 @default.
• W2006272302 creator A5070856330 @default.
• W2006272302 date "2011-11-28" @default.
• W2006272302 modified "2023-09-30" @default.
• W2006272302 title "Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids" @default.
• W2006272302 cites W1522493119 @default.
• W2006272302 cites W169438481 @default.
• W2006272302 cites W1905183497 @default.
• W2006272302 cites W1975464764 @default.
• W2006272302 cites W1979544330 @default.
• W2006272302 cites W1981853190 @default.
• W2006272302 cites W1986458631 @default.
• W2006272302 cites W1987995349 @default.
• W2006272302 cites W2027621993 @default.
• W2006272302 cites W2033795404 @default.
• W2006272302 cites W2039516370 @default.
• W2006272302 cites W2042063022 @default.
• W2006272302 cites W2044994347 @default.
• W2006272302 cites W2049685764 @default.
• W2006272302 cites W2058338279 @default.
• W2006272302 cites W2060080779 @default.
• W2006272302 cites W2064753081 @default.
• W2006272302 cites W2065934464 @default.
• W2006272302 cites W2075152713 @default.
• W2006272302 cites W2082471729 @default.
• W2006272302 cites W2088028046 @default.
• W2006272302 cites W2116471216 @default.
• W2006272302 cites W2119615258 @default.
• W2006272302 cites W2129558265 @default.
• W2006272302 cites W2139468129 @default.
• W2006272302 cites W2139551007 @default.
• W2006272302 cites W2140824976 @default.
• W2006272302 cites W2142860698 @default.
• W2006272302 cites W2153820061 @default.
• W2006272302 cites W2160563322 @default.
• W2006272302 cites W303825309 @default.
• W2006272302 cites W76618276 @default.
• W2006272302 doi "https://doi.org/10.1073/pnas.1117937108" @default.
• W2006272302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3250133" @default.
• W2006272302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22123968" @default.
• W2006272302 hasPublicationYear "2011" @default.
• W2006272302 type Work @default.
• W2006272302 sameAs 2006272302 @default.
• W2006272302 citedByCount "112" @default.
• W2006272302 countsByYear W20062723022012 @default.
• W2006272302 countsByYear W20062723022013 @default.
• W2006272302 countsByYear W20062723022014 @default.
• W2006272302 countsByYear W20062723022015 @default.
• W2006272302 countsByYear W20062723022016 @default.
• W2006272302 countsByYear W20062723022017 @default.
• W2006272302 countsByYear W20062723022018 @default.
• W2006272302 countsByYear W20062723022019 @default.
• W2006272302 countsByYear W20062723022020 @default.
• W2006272302 countsByYear W20062723022021 @default.
• W2006272302 countsByYear W20062723022022 @default.
• W2006272302 countsByYear W20062723022023 @default.
• W2006272302 crossrefType "journal-article" @default.
• W2006272302 hasAuthorship W2006272302A5017398792 @default.
• W2006272302 hasAuthorship W2006272302A5024049281 @default.
• W2006272302 hasAuthorship W2006272302A5048444476 @default.
• W2006272302 hasAuthorship W2006272302A5070856330 @default.
• W2006272302 hasBestOaLocation W20062723021 @default.
• W2006272302 hasConcept C102744134 @default.
• W2006272302 hasConcept C104317684 @default.
• W2006272302 hasConcept C125832826 @default.
• W2006272302 hasConcept C147727578 @default.
• W2006272302 hasConcept C148196450 @default.
• W2006272302 hasConcept C2778354886 @default.
• W2006272302 hasConcept C30481170 @default.
• W2006272302 hasConcept C54355233 @default.
• W2006272302 hasConcept C552990157 @default.
• W2006272302 hasConcept C73397532 @default.
• W2006272302 hasConcept C8502773 @default.
• W2006272302 hasConcept C86803240 @default.
• W2006272302 hasConcept C95444343 @default.
• W2006272302 hasConceptScore W2006272302C102744134 @default.
• W2006272302 hasConceptScore W2006272302C104317684 @default.
• W2006272302 hasConceptScore W2006272302C125832826 @default.
• W2006272302 hasConceptScore W2006272302C147727578 @default.
• W2006272302 hasConceptScore W2006272302C148196450 @default.
• W2006272302 hasConceptScore W2006272302C2778354886 @default.
• W2006272302 hasConceptScore W2006272302C30481170 @default.
• W2006272302 hasConceptScore W2006272302C54355233 @default.
• W2006272302 hasConceptScore W2006272302C552990157 @default.
• W2006272302 hasConceptScore W2006272302C73397532 @default.
• W2006272302 hasConceptScore W2006272302C8502773 @default.
• W2006272302 hasConceptScore W2006272302C86803240 @default.
• W2006272302 hasConceptScore W2006272302C95444343 @default.
• W2006272302 hasIssue "50" @default.
• W2006272302 hasLocation W20062723021 @default.
• W2006272302 hasLocation W20062723022 @default.
• W2006272302 hasLocation W20062723023 @default.
• W2006272302 hasLocation W20062723024 @default.
• W2006272302 hasLocation W20062723025 @default.

• next