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- W2006290185 abstract "Anemia in children with chronic kidney disease (CKD) is associated with increased morbidity and mortality. In this Review, Atkinson and Furth outline the adverse effects associated with the anemia of CKD in children and discuss factors that contribute to the development of anemia in this population. Treatment strategies and the challenges of managing this condition in children with CKD are also discussed. Anemia is a common comorbidity in children with chronic kidney disease (CKD). This condition is associated with multiple adverse clinical consequences and its management is a core component of nephrology care. Increased morbidity and mortality, increased risk of cardiovascular disease and decreased quality of life have been associated with anemia of CKD in children. Although numerous complex factors interact in the development of this anemia, erythropoietin deficiency and iron dysregulation (including iron deficiency and iron-restricted erythropoiesis) are the primary causes. In addition to iron supplementation, erythropoietin-stimulating agents (ESAs) can effectively treat this anemia, but there are important differences in ESA dose requirements between children and adults. Also, hyporesponsiveness to ESA therapy is a common problem in children with CKD. Although escalating ESA doses to target increased hemoglobin values in adults has been associated with adverse outcomes, no studies have demonstrated this association in children. The question of appropriate target hemoglobin levels in children, and the approach by which to achieve these levels, remains under debate. Randomized, controlled studies are needed to evaluate whether normalization of hemoglobin concentrations is beneficial to children, and whether this practice is associated with increased risks." @default.
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- W2006290185 date "2011-09-06" @default.
- W2006290185 modified "2023-10-10" @default.
- W2006290185 title "Anemia in children with chronic kidney disease" @default.
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- W2006290185 doi "https://doi.org/10.1038/nrneph.2011.115" @default.
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