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- W2006291295 abstract "Among the earliest invariant neuropathological changes in Alzheimer's disease (AD) is the degeneration of vulnerable hippocampal CA1 and subicular pyramidal neurons. Semaphorin 3A (Sema3A) is a secreted protein that functions in signaling growth cone collapse, chemorepulsion and neuronal apoptosis during early development of the central nervous system. In this report we show that accumulation of an internalized form of Sema3A is associated with degeneration of neurons in vulnerable fields of the hippocampus during AD. Accumulation of Sema3A overlaps the appearance of phosphorylated MAP1B and tau in many neurons, suggesting that Sema3A signaling at some level may be coupled to these previously identified cytoskeletal markers of neurodegeneration. Consistent with this, we isolated and partially characterized a multiprotein complex from the hippocampus of patients with AD that contains phosphorylated MAP1B, collapsin-response mediator protein 2 (CRMP-2), Plexins A1 and A2, and a processed form of Sema3A. A model is presented in which aberrant release of Sema3A from expressing neurons in the subiculum during AD results in the internalization and transport of Sema3A from this field to CA1. Within the context of the myriad of potential insults that contribute to Alzheimer's and other neurodegenerative diseases, the bioactivity of Sema3A may contribute either directly to neurodegeneration by inducing neuronal collapse, or indirectly by abrogating the recovery capabilities of adult neurons faced with these insults." @default.
- W2006291295 created "2016-06-24" @default.
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- W2006291295 creator A5079003235 @default.
- W2006291295 date "2004-09-27" @default.
- W2006291295 modified "2023-10-10" @default.
- W2006291295 title "A role for semaphorin 3A signaling in the degeneration of hippocampal neurons during Alzheimer's disease" @default.
- W2006291295 cites W1570260604 @default.
- W2006291295 cites W1653222112 @default.
- W2006291295 cites W170210892 @default.
- W2006291295 cites W1706681742 @default.
- W2006291295 cites W1788354698 @default.
- W2006291295 cites W1911014954 @default.
- W2006291295 cites W1927563061 @default.
- W2006291295 cites W1967534538 @default.
- W2006291295 cites W1972114796 @default.
- W2006291295 cites W1974092008 @default.
- W2006291295 cites W1977560589 @default.
- W2006291295 cites W1978276744 @default.
- W2006291295 cites W1980149320 @default.
- W2006291295 cites W1986044799 @default.
- W2006291295 cites W1990983421 @default.
- W2006291295 cites W1992411166 @default.
- W2006291295 cites W1992423329 @default.
- W2006291295 cites W1993174592 @default.
- W2006291295 cites W1999224926 @default.
- W2006291295 cites W2000480493 @default.
- W2006291295 cites W2002412835 @default.
- W2006291295 cites W2004027050 @default.
- W2006291295 cites W2005809709 @default.
- W2006291295 cites W2008219426 @default.
- W2006291295 cites W2009713506 @default.
- W2006291295 cites W2013184812 @default.
- W2006291295 cites W2015345898 @default.
- W2006291295 cites W2015738018 @default.
- W2006291295 cites W2016390889 @default.
- W2006291295 cites W2022971351 @default.
- W2006291295 cites W2026465178 @default.
- W2006291295 cites W2029773027 @default.
- W2006291295 cites W2035507981 @default.
- W2006291295 cites W2036265417 @default.
- W2006291295 cites W2038036971 @default.
- W2006291295 cites W2038803405 @default.
- W2006291295 cites W2045466989 @default.
- W2006291295 cites W2046479957 @default.
- W2006291295 cites W2046624741 @default.
- W2006291295 cites W2047166961 @default.
- W2006291295 cites W2048133927 @default.
- W2006291295 cites W2048560678 @default.
- W2006291295 cites W2051053924 @default.
- W2006291295 cites W2052742260 @default.
- W2006291295 cites W2054306942 @default.
- W2006291295 cites W2054619408 @default.
- W2006291295 cites W2055553278 @default.
- W2006291295 cites W2055613750 @default.
- W2006291295 cites W2056961001 @default.
- W2006291295 cites W2060240421 @default.
- W2006291295 cites W2062878891 @default.
- W2006291295 cites W2063512758 @default.
- W2006291295 cites W2068224188 @default.
- W2006291295 cites W2070699124 @default.
- W2006291295 cites W2071148852 @default.
- W2006291295 cites W2071241028 @default.
- W2006291295 cites W2076606893 @default.
- W2006291295 cites W2079449212 @default.
- W2006291295 cites W2083451944 @default.
- W2006291295 cites W2083689477 @default.
- W2006291295 cites W2084652820 @default.
- W2006291295 cites W2102991194 @default.
- W2006291295 cites W2104373322 @default.
- W2006291295 cites W2104773372 @default.
- W2006291295 cites W2104962877 @default.
- W2006291295 cites W2111405228 @default.
- W2006291295 cites W2118999426 @default.
- W2006291295 cites W2122825604 @default.
- W2006291295 cites W2126024001 @default.
- W2006291295 cites W2126402843 @default.
- W2006291295 cites W2129662130 @default.
- W2006291295 cites W2129677617 @default.
- W2006291295 cites W2133649247 @default.
- W2006291295 cites W2135841642 @default.
- W2006291295 cites W2136637949 @default.
- W2006291295 cites W2142603285 @default.
- W2006291295 cites W2154541766 @default.
- W2006291295 cites W2163339962 @default.
- W2006291295 cites W2308230214 @default.
- W2006291295 cites W2321725396 @default.
- W2006291295 cites W2344433860 @default.
- W2006291295 cites W4250109928 @default.
- W2006291295 cites W4256014245 @default.
- W2006291295 cites W52042314 @default.
- W2006291295 doi "https://doi.org/10.1111/j.1471-4159.2004.02766.x" @default.