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- W2006291444 abstract "Oligosaccharide moieties of cell surface glycoconjugates are thought to be involved in recognition events associated with infectious diseases. Treatment of Streptococcus pneumoniae (which exhibits well defined surface lectins) with subinhibitory concentrations of the antibiotic tunicamycin was found to block the protein glycosylation of the bacterial surfaces. Since bacterial lectins (adhesins) are in most cases glycoproteins and play an important role in the organ specificity of infectious diseases, adhesion of Streptococcus pneumoniae to frozen sections of lung, meninges and kidney (from Balb/c-mice) was almost totally lacking after inhibition of the biosynthesis of N-linked carbohydrate chains which are important for an adequate lectin function. Chemiluminescence measurements of human granulocyte stimulation yielded results suggesting a great importance of lectin-carbohydrate interactions in this process, too. These experimental data indicate that the presence of specific cell surface carbohydrates is required for a successful completion of the adhesion phase of pathogenic bacteria in infectious diseases and for the induction of granulocyte stimulation. Oligosaccharidketten zellulärer (bakterieller) Membranglykokonjugate sind offensichtlich beteiligt am Erkennungs- und Adhäsionsprozeß pathogener Erreger bei Infektionskrankheiten. Inkubation von Streptococcus pneumoniae (der definierte Membranlektine aufweist) mit subinhibitorischen Konzentrationen des Antibiotikums Tunicamycin hemmt die Proteinglykosylierung der bakteriellen Zellwand. Bakterielle Lektine (Adhäsine) sind in den meisten Fällen Glykoproteine und für die organ-spezifische mikrobielle Besiedlung verantwortlich. Kryotomschnitte verschiedener Organe (Lunge, Niere, Meningen) von Balb/c-Mäusen offenbarten nach Inkubation mit Tunicamycin-behandelten Pneumokokken eine drastische Reduktion adhärierender Bakterien. Die unvollständige Biosynthese der Kohlenhydratketten bakterieller Membranlektine ist offenbar die Ursache für deren Funktionseinbuße. Die Messung der Chemilumineszenz menschlicher Granulozyten läßt eine Lektin-Kohlenhydrat-Interaktion beim Stimulierungsprozeß dieser Zellen vermuten. Spezifische Zellwandkohlenhydrate sind an der Adhäsion pathogener Bakterien (und somit an Infektionskrankheiten) sowie an der Stimulierung von Granulozyten maßgeblich beteiligt." @default.
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- W2006291444 date "1987-08-01" @default.
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- W2006291444 title "Modification of glycosylation by tunicamycin treatment inhibits lectin-mediated adhesion of Streptococcus pneumoniae to various tissues" @default.
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- W2006291444 doi "https://doi.org/10.1016/s0176-6724(87)80027-5" @default.
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