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- W2006292808 abstract "Severe thermal injuries invoke an initial systemic inflammatory response that is followed by a compensatory anti-inflammatory phase [ 1 Schwacha M.G. Macrophages and post-burn immune dysfunction. Burns. 2003; 29: 1 Abstract Full Text Full Text PDF PubMed Scopus (237) Google Scholar ]. This counter-regulatory phase can induce a relative state of immunosuppression that may predispose to the development of septic shock and multiple organ dysfunction syndrome [ 2 Sparkes B.G. Immunological responses to thermal injury. Burns. 1997; 23: 106 Abstract Full Text PDF PubMed Scopus (89) Google Scholar ]. A key element of this post-burn immune dysfunction involves alteration of macrophage activity, including decreased phagocytic abilities [ 1 Schwacha M.G. Macrophages and post-burn immune dysfunction. Burns. 2003; 29: 1 Abstract Full Text Full Text PDF PubMed Scopus (237) Google Scholar , 3 Stephan R.N. Ayala A. Harkema J.M. et al. Mechanism of immunosuppression following hemorrhage: Defective antigen presentation by macrophages. J Surg Res. 1989; 46: 553 Abstract Full Text PDF PubMed Scopus (42) Google Scholar ] and decreased major histocompatibility complex (MHC) class II expression, with associated increased mortality and other complications [ 1 Schwacha M.G. Macrophages and post-burn immune dysfunction. Burns. 2003; 29: 1 Abstract Full Text Full Text PDF PubMed Scopus (237) Google Scholar , 4 Venet F. Tissot S. Debard A.L. et al. Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock. Crit Care Med. 2007; 35: 1910 Crossref PubMed Scopus (120) Google Scholar , 5 Monneret G. Lepape A. Voirin N. et al. Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock. Intensive Care Med. 2006; 32: 1175 Crossref PubMed Scopus (365) Google Scholar ]. In addition, increased PGE2 and decreased IL-12 production by macrophages promote a Th2-mediated humoral response and increased production of the anti-inflammatory cytokines IL-4 and IL-10 [ 1 Schwacha M.G. Macrophages and post-burn immune dysfunction. Burns. 2003; 29: 1 Abstract Full Text Full Text PDF PubMed Scopus (237) Google Scholar , 6 Schwacha M.G. Chung C.S. Ayala A. et al. Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury. Am J Physiol Cell Physiol. 2002; 282: C263 Crossref PubMed Scopus (41) Google Scholar ]." @default.
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- W2006292808 date "2009-12-01" @default.
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- W2006292808 title "Rescuing Macrophage Function Following Severe Thermal Injury" @default.
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