FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006293792> ?p ?o ?g. }

• W2006293792 endingPage "622" @default.
• W2006293792 startingPage "615" @default.
• W2006293792 abstract "Glycyrrhizin (GL), extracted from the Glycyrrhiza glabra L., is active triterpenoid saponin components. However, due to its impermeability across the gastrointestinal mucosa, oral bioavailability of the drug was relatively low. To improve its oral bioavailability, formulation of GL as sodium deoxycholate/phospholipid-mixed nanomicelles (SDC/PL-MMs) has been performed in this study. GL-SDC/PL-MMs were produced by a film dispersion method and then investigated using photon correlation spectroscopy (PCS), zeta potential measurement, as well as its physical stability after storage for 10, 20, 30, 60, 90 and 120 days. To verify the theoretical hypothesis, pharmacokinetics and pharmacodynamic studies based on carbon tetrachloride (CCl4)-induced acute liver injury was investigated. Results showed that a narrow size distributed nanomicelles with a mean particle size of 82.99 ± 7.5 nm and a zeta potential of −32.23 ± 1.05 mV was obtained. In the pharmacokinetics, GL-SDC/PL-MMs show a significant superiority in AUC0–t, Cmax and other pharmacokinetic parameters compared with the control group. In the pharmacodynamic studies, compared with the bifendate control group, GL-SDC/PL-MMs showed an equivalent effect in reducing alanine aminotransferase (ALT), aspartate aminotransferase (AST) and improving the pathological changes of liver tissue. These results revealed that SDC/PL-MMs could enhance GL absorption in gastrointestinal tract and pharmacodynamic effect in the treatment of acute liver injury caused by CCl4, and SDC/PL-MMs might be a good choice for oral delivery of poor bioavailability drug like GL." @default.
• W2006293792 created "2016-06-24" @default.
• W2006293792 creator A5023925767 @default.
• W2006293792 creator A5031337826 @default.
• W2006293792 creator A5039723388 @default.
• W2006293792 creator A5041357914 @default.
• W2006293792 creator A5045461818 @default.
• W2006293792 creator A5051178495 @default.
• W2006293792 creator A5054111036 @default.
• W2006293792 creator A5079730676 @default.
• W2006293792 creator A5081067381 @default.
• W2006293792 date "2012-06-23" @default.
• W2006293792 modified "2023-10-06" @default.
• W2006293792 title "Improvement of oral bioavailability of glycyrrhizin by sodium deoxycholate/phospholipid-mixed nanomicelles" @default.
• W2006293792 cites W1968664136 @default.
• W2006293792 cites W1969569989 @default.
• W2006293792 cites W1974497548 @default.
• W2006293792 cites W1979330920 @default.
• W2006293792 cites W1986124680 @default.
• W2006293792 cites W1986193053 @default.
• W2006293792 cites W1994395817 @default.
• W2006293792 cites W1995147666 @default.
• W2006293792 cites W2018101819 @default.
• W2006293792 cites W2049459060 @default.
• W2006293792 cites W2057600084 @default.
• W2006293792 cites W2059997493 @default.
• W2006293792 cites W2064393402 @default.
• W2006293792 cites W2065106251 @default.
• W2006293792 cites W2066080391 @default.
• W2006293792 cites W2069235788 @default.
• W2006293792 cites W2078230273 @default.
• W2006293792 cites W2130622649 @default.
• W2006293792 cites W2409405022 @default.
• W2006293792 doi "https://doi.org/10.3109/1061186x.2012.702770" @default.
• W2006293792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22726209" @default.
• W2006293792 hasPublicationYear "2012" @default.
• W2006293792 type Work @default.
• W2006293792 sameAs 2006293792 @default.
• W2006293792 citedByCount "36" @default.
• W2006293792 countsByYear W20062937922013 @default.
• W2006293792 countsByYear W20062937922014 @default.
• W2006293792 countsByYear W20062937922015 @default.
• W2006293792 countsByYear W20062937922016 @default.
• W2006293792 countsByYear W20062937922017 @default.
• W2006293792 countsByYear W20062937922018 @default.
• W2006293792 countsByYear W20062937922019 @default.
• W2006293792 countsByYear W20062937922020 @default.
• W2006293792 countsByYear W20062937922021 @default.
• W2006293792 countsByYear W20062937922022 @default.
• W2006293792 countsByYear W20062937922023 @default.
• W2006293792 crossrefType "journal-article" @default.
• W2006293792 hasAuthorship W2006293792A5023925767 @default.
• W2006293792 hasAuthorship W2006293792A5031337826 @default.
• W2006293792 hasAuthorship W2006293792A5039723388 @default.
• W2006293792 hasAuthorship W2006293792A5041357914 @default.
• W2006293792 hasAuthorship W2006293792A5045461818 @default.
• W2006293792 hasAuthorship W2006293792A5051178495 @default.
• W2006293792 hasAuthorship W2006293792A5054111036 @default.
• W2006293792 hasAuthorship W2006293792A5079730676 @default.
• W2006293792 hasAuthorship W2006293792A5081067381 @default.
• W2006293792 hasConcept C111113717 @default.
• W2006293792 hasConcept C112705442 @default.
• W2006293792 hasConcept C155672457 @default.
• W2006293792 hasConcept C171250308 @default.
• W2006293792 hasConcept C181389837 @default.
• W2006293792 hasConcept C185592680 @default.
• W2006293792 hasConcept C192562407 @default.
• W2006293792 hasConcept C22979827 @default.
• W2006293792 hasConcept C2776332754 @default.
• W2006293792 hasConcept C2777056448 @default.
• W2006293792 hasConcept C71924100 @default.
• W2006293792 hasConcept C86181022 @default.
• W2006293792 hasConcept C98274493 @default.
• W2006293792 hasConceptScore W2006293792C111113717 @default.
• W2006293792 hasConceptScore W2006293792C112705442 @default.
• W2006293792 hasConceptScore W2006293792C155672457 @default.
• W2006293792 hasConceptScore W2006293792C171250308 @default.
• W2006293792 hasConceptScore W2006293792C181389837 @default.
• W2006293792 hasConceptScore W2006293792C185592680 @default.
• W2006293792 hasConceptScore W2006293792C192562407 @default.
• W2006293792 hasConceptScore W2006293792C22979827 @default.
• W2006293792 hasConceptScore W2006293792C2776332754 @default.
• W2006293792 hasConceptScore W2006293792C2777056448 @default.
• W2006293792 hasConceptScore W2006293792C71924100 @default.
• W2006293792 hasConceptScore W2006293792C86181022 @default.
• W2006293792 hasConceptScore W2006293792C98274493 @default.
• W2006293792 hasIssue "7" @default.
• W2006293792 hasLocation W20062937921 @default.
• W2006293792 hasLocation W20062937922 @default.
• W2006293792 hasOpenAccess W2006293792 @default.
• W2006293792 hasPrimaryLocation W20062937921 @default.
• W2006293792 hasRelatedWork W1534373964 @default.
• W2006293792 hasRelatedWork W1969574919 @default.
• W2006293792 hasRelatedWork W2035255429 @default.
• W2006293792 hasRelatedWork W2068318921 @default.
• W2006293792 hasRelatedWork W2075612064 @default.
• W2006293792 hasRelatedWork W2316174115 @default.
• W2006293792 hasRelatedWork W2362278450 @default.

• next