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- W2006295013 abstract "The aims of this study were to validate and compare HPLC and LCMSMS analytical methods and their applicability for the quantitation of imatinib in human plasma. A total of 50 patients with chronic myeloid leukemia (CML) in chronic phase (CP) receiving 400 mg/day imatinib were enrolled in the study. Drug levels were determined by HPLC–UV and LCMSMS. HPLC intra-day accuracy ranged from 100.51 to 103.19%. LCMSMS accuracy ranged from 89.72 to 106.29%. The correlation coefficient between both methods was r2 = 0.96. HPLC can be used for imatinib levels’ determinations in patients accurately and precisely." @default.
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- W2006295013 date "2010-06-01" @default.
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- W2006295013 title "Determination of imatinib plasma levels in patients with chronic myeloid leukemia by high performance liquid chromatography–ultraviolet detection and liquid chromatography–tandem mass spectrometry: Methods’ comparison" @default.
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- W2006295013 doi "https://doi.org/10.1016/j.leukres.2009.08.005" @default.
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