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• W2006298354 abstract "The present study investigated in vitro the regulatory effects of T helper 1 (Th1)‐type (interferon‐γ, IFN‐γ; interleukin‐12, IL‐12) and Th2‐type cytokines (IL‐10, IL‐13) on Onchocerca volvulus ‐specific cellular reactivity in onchocerciasis patients, and in exposed endemic control individuals presenting no clinical and parasitological signs of disease. In both patients and controls, addition of IL‐10 dose‐dependently depressed O. volvulus antigen (OvAg)‐specific cellular proliferation, and peripheral blood mononuclear cells (PBMC) from patients who were more sensitive to the suppressive effect of IL‐10 than those from endemic controls. However, neutralization of IL‐10 by specific antibody did not reverse cellular hyporesponsiveness. In contrast to the inhibitory effects of IL‐10, exogenous IL‐12 and IL‐13 augmented PBMC proliferative responses to OvAg both in patients and controls ( P <0·01) and neutralizing of IL‐12 or IL‐13 significantly decreased OvAg‐specific proliferation in both groups. Exogenous IFN‐γ did not activate OvAg‐specific proliferative responses in patients, but anti‐IFN‐γ antibodies abolished cellular reactivity to OvAg. Antibody to IL‐10 increased ( P <0·05) OvAg‐specific production of IL‐5, IL‐12 and IFN‐γ, and inversely, anti‐IFN‐γ enhanced IL‐10 (in patients only) and IL‐5 and IL‐13 in both patients and controls. Neutralization of IL‐12 activated OvAg‐specific production of IL‐10, IL‐2 and IFN‐γ. In conclusion, despite of an overproduction of IL‐10, which suppressed cellular reactivity in patients and control individuals, OvAg‐specific cellular responses were activated in vitro by exogenous supplementation with IL‐12 and IL‐13, and cytokine neutralization experiments confirmed that distinct type 1 and type 2 T helper cytokines cross‐regulate expression and magnitude of O. volvulus ‐specific cellular responsiveness in humans." @default.
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• W2006298354 date "1999-06-01" @default.
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• W2006298354 title "Regulatory effects of Th1‐type (IFN‐γ, IL‐12) and Th2‐type cytokines (IL‐10, IL‐13) on parasite‐specific cellular responsiveness in <i>Onchocerca volvulus</i>‐infected humans and exposed endemic controls" @default.
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• W2006298354 doi "https://doi.org/10.1046/j.1365-2567.1999.00018.x" @default.
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