FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006301175> ?p ?o ?g. }

• W2006301175 endingPage "H2810" @default.
• W2006301175 startingPage "H2802" @default.
• W2006301175 abstract "The lipoprotein lipase (LPL)-augmenting property of lysophosphatidylcholine requires the formation of lysophosphatidic acid (LPA) ( J Mol Cell Cardiol 37: 931–938, 2004). Given that the actin cytoskeleton has been implicated in regulating cardiomyocyte LPL, we examined whether LPL secretion after LPA involves actin cytoskeleton reassembly. Incubation of myocytes with LPA (1–100 nM) increased basal and heparin-releasable LPL (HR-LPL), an effect that was independent of shifts in LPL mRNA. The influence of LPA on myocyte LPL was reflected at the coronary lumen, with substantial increases of the enzyme at this location. Incubation of myocytes with cytochalasin D not only blocked LPA-induced augmentation of HR-LPL but also abrogated filamentous actin formation. These effects of LPA were likely receptor mediated. Exposure of myocytes to LPA facilitated significant membrane translocation of RhoA and its downstream effector Rho kinase I (ROCK I), and blocking this effect with Y-27632 appreciably reduced basal and HR-LPL activity. Incubation of adipose tissue with LPA also significantly enhanced basal and HR-LPL activity, suggesting that sarcomeric actin likely has a limited role in influencing the LPL secretory function of LPA in the myocyte. Comparable to LPA, hyperglycemia also caused significant membrane translocation of RhoA and ROCK I in hearts isolated from diazoxide-treated animals, effects that were abrogated using insulin. Overall, our data suggest that comparable to hyperglycemia, LPA-induced increases in cardiac LPL occurred via posttranscriptional mechanisms and processes that likely required RhoA activation and actin polymerization. Whether this increase in LPL augments triglyceride deposition in the heart leading to eventual impairment in contractile function is currently unknown." @default.
• W2006301175 created "2016-06-24" @default.
• W2006301175 creator A5008981001 @default.
• W2006301175 creator A5010026508 @default.
• W2006301175 creator A5015320782 @default.
• W2006301175 creator A5045559776 @default.
• W2006301175 creator A5061656649 @default.
• W2006301175 creator A5066679945 @default.
• W2006301175 creator A5074575955 @default.
• W2006301175 creator A5089688063 @default.
• W2006301175 creator A5091043000 @default.
• W2006301175 date "2005-06-01" @default.
• W2006301175 modified "2023-09-30" @default.
• W2006301175 title "Lysophosphatidic acid-mediated augmentation of cardiomyocyte lipoprotein lipase involves actin cytoskeleton reorganization" @default.
• W2006301175 cites W1798715143 @default.
• W2006301175 cites W191405060 @default.
• W2006301175 cites W1952404770 @default.
• W2006301175 cites W1967600689 @default.
• W2006301175 cites W1987229312 @default.
• W2006301175 cites W1988621431 @default.
• W2006301175 cites W1991852201 @default.
• W2006301175 cites W1992907326 @default.
• W2006301175 cites W1993057072 @default.
• W2006301175 cites W1995150742 @default.
• W2006301175 cites W1998414644 @default.
• W2006301175 cites W1998899602 @default.
• W2006301175 cites W2001808939 @default.
• W2006301175 cites W2003952140 @default.
• W2006301175 cites W2004576418 @default.
• W2006301175 cites W2005432768 @default.
• W2006301175 cites W2006680322 @default.
• W2006301175 cites W2012898950 @default.
• W2006301175 cites W2013023878 @default.
• W2006301175 cites W2017502152 @default.
• W2006301175 cites W2019274593 @default.
• W2006301175 cites W2020510771 @default.
• W2006301175 cites W2023531846 @default.
• W2006301175 cites W2025288722 @default.
• W2006301175 cites W2032074620 @default.
• W2006301175 cites W2032511565 @default.
• W2006301175 cites W2045234862 @default.
• W2006301175 cites W2053692048 @default.
• W2006301175 cites W2054342171 @default.
• W2006301175 cites W2059318962 @default.
• W2006301175 cites W2060477269 @default.
• W2006301175 cites W2066640283 @default.
• W2006301175 cites W2077537799 @default.
• W2006301175 cites W2077603983 @default.
• W2006301175 cites W2089635824 @default.
• W2006301175 cites W2091466360 @default.
• W2006301175 cites W2092868396 @default.
• W2006301175 cites W2095699364 @default.
• W2006301175 cites W2096791952 @default.
• W2006301175 cites W2109974996 @default.
• W2006301175 cites W2111792754 @default.
• W2006301175 cites W2122909568 @default.
• W2006301175 cites W2124966303 @default.
• W2006301175 cites W2128076901 @default.
• W2006301175 cites W2129246481 @default.
• W2006301175 cites W2130172628 @default.
• W2006301175 cites W2131431703 @default.
• W2006301175 cites W2131578695 @default.
• W2006301175 cites W2133229697 @default.
• W2006301175 cites W2135212786 @default.
• W2006301175 cites W2139865525 @default.
• W2006301175 cites W2145708730 @default.
• W2006301175 cites W2150148761 @default.
• W2006301175 cites W2159090847 @default.
• W2006301175 cites W2161773048 @default.
• W2006301175 cites W2163133008 @default.
• W2006301175 cites W2170850197 @default.
• W2006301175 cites W2263957133 @default.
• W2006301175 cites W2265145202 @default.
• W2006301175 cites W2324387122 @default.
• W2006301175 cites W2415367567 @default.
• W2006301175 doi "https://doi.org/10.1152/ajpheart.01162.2004" @default.
• W2006301175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15681706" @default.
• W2006301175 hasPublicationYear "2005" @default.
• W2006301175 type Work @default.
• W2006301175 sameAs 2006301175 @default.
• W2006301175 citedByCount "36" @default.
• W2006301175 countsByYear W20063011752012 @default.
• W2006301175 countsByYear W20063011752013 @default.
• W2006301175 countsByYear W20063011752014 @default.
• W2006301175 countsByYear W20063011752015 @default.
• W2006301175 countsByYear W20063011752016 @default.
• W2006301175 countsByYear W20063011752017 @default.
• W2006301175 countsByYear W20063011752018 @default.
• W2006301175 countsByYear W20063011752021 @default.
• W2006301175 countsByYear W20063011752023 @default.
• W2006301175 crossrefType "journal-article" @default.
• W2006301175 hasAuthorship W2006301175A5008981001 @default.
• W2006301175 hasAuthorship W2006301175A5010026508 @default.
• W2006301175 hasAuthorship W2006301175A5015320782 @default.
• W2006301175 hasAuthorship W2006301175A5045559776 @default.
• W2006301175 hasAuthorship W2006301175A5061656649 @default.
• W2006301175 hasAuthorship W2006301175A5066679945 @default.
• W2006301175 hasAuthorship W2006301175A5074575955 @default.

• next