Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006301750> ?p ?o ?g. }
- W2006301750 endingPage "355" @default.
- W2006301750 startingPage "347" @default.
- W2006301750 abstract "The dorsal and median raphe nuclei were examined with immunocytochemistry to display the 5-HT neurones in 16 cases of post-mortem-proven Alzheimer's disease (AD) and 12 age and sex-matched controls. The AD cases had been prospectively assessed during life for expression of behavioural changes as well as for cognitive decline. A significant (P < 0.001) 41% reduction in density of dorsal raphe neurones was found along with a significant (P < 0.02) 29% reduction in density of median raphe neurones in AD. There were significantly more neurofibrillary tangles in both dorsal and median raphe nuclei in AD than in controls (P < 0.001). There was no correlation between reduction in neurone density in these nuclei and behavioural change, cognitive decline, neurofibrillary tangle counts in these nuclei or plaque and tangle pathology in frontal and temporal cortex. It was concluded from these findings that the raphe nuclei are significantly affected by the pathology of AD and that plasticity in the 5-HT system is the probable reason for the lack of correlation of reduced 5-HT neurone density and clinical disease parameters." @default.
- W2006301750 created "2016-06-24" @default.
- W2006301750 creator A5004149008 @default.
- W2006301750 creator A5014932655 @default.
- W2006301750 creator A5026657319 @default.
- W2006301750 creator A5043571818 @default.
- W2006301750 creator A5073948730 @default.
- W2006301750 creator A5077578611 @default.
- W2006301750 date "2000-08-01" @default.
- W2006301750 modified "2023-09-24" @default.
- W2006301750 title "Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer’s disease prospectively assessed for behavioural changes" @default.
- W2006301750 cites W1688235741 @default.
- W2006301750 cites W1725663634 @default.
- W2006301750 cites W1977648717 @default.
- W2006301750 cites W1980025743 @default.
- W2006301750 cites W1981495015 @default.
- W2006301750 cites W1982643751 @default.
- W2006301750 cites W1985098185 @default.
- W2006301750 cites W1986423695 @default.
- W2006301750 cites W1990172803 @default.
- W2006301750 cites W2006937939 @default.
- W2006301750 cites W2010955438 @default.
- W2006301750 cites W2011279980 @default.
- W2006301750 cites W2014892312 @default.
- W2006301750 cites W2021121643 @default.
- W2006301750 cites W2023055592 @default.
- W2006301750 cites W2023310313 @default.
- W2006301750 cites W2023586735 @default.
- W2006301750 cites W2025543844 @default.
- W2006301750 cites W2028666162 @default.
- W2006301750 cites W2039765555 @default.
- W2006301750 cites W2040041175 @default.
- W2006301750 cites W2050665230 @default.
- W2006301750 cites W2051033492 @default.
- W2006301750 cites W2052261143 @default.
- W2006301750 cites W2053051596 @default.
- W2006301750 cites W2064247269 @default.
- W2006301750 cites W2064659680 @default.
- W2006301750 cites W2072150523 @default.
- W2006301750 cites W2085447556 @default.
- W2006301750 cites W2086115560 @default.
- W2006301750 cites W2087908526 @default.
- W2006301750 cites W2119306020 @default.
- W2006301750 cites W2132551988 @default.
- W2006301750 cites W2136631323 @default.
- W2006301750 cites W2146729934 @default.
- W2006301750 cites W2152185487 @default.
- W2006301750 cites W2152692871 @default.
- W2006301750 cites W2153154672 @default.
- W2006301750 cites W2160456898 @default.
- W2006301750 cites W2164472724 @default.
- W2006301750 cites W2171405125 @default.
- W2006301750 doi "https://doi.org/10.1046/j.1365-2990.2000.00254.x" @default.
- W2006301750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10931368" @default.
- W2006301750 hasPublicationYear "2000" @default.
- W2006301750 type Work @default.
- W2006301750 sameAs 2006301750 @default.
- W2006301750 citedByCount "94" @default.
- W2006301750 countsByYear W20063017502012 @default.
- W2006301750 countsByYear W20063017502013 @default.
- W2006301750 countsByYear W20063017502014 @default.
- W2006301750 countsByYear W20063017502015 @default.
- W2006301750 countsByYear W20063017502016 @default.
- W2006301750 countsByYear W20063017502017 @default.
- W2006301750 countsByYear W20063017502019 @default.
- W2006301750 countsByYear W20063017502020 @default.
- W2006301750 countsByYear W20063017502021 @default.
- W2006301750 countsByYear W20063017502022 @default.
- W2006301750 countsByYear W20063017502023 @default.
- W2006301750 crossrefType "journal-article" @default.
- W2006301750 hasAuthorship W2006301750A5004149008 @default.
- W2006301750 hasAuthorship W2006301750A5014932655 @default.
- W2006301750 hasAuthorship W2006301750A5026657319 @default.
- W2006301750 hasAuthorship W2006301750A5043571818 @default.
- W2006301750 hasAuthorship W2006301750A5073948730 @default.
- W2006301750 hasAuthorship W2006301750A5077578611 @default.
- W2006301750 hasConcept C126322002 @default.
- W2006301750 hasConcept C142642502 @default.
- W2006301750 hasConcept C142724271 @default.
- W2006301750 hasConcept C169760540 @default.
- W2006301750 hasConcept C170493617 @default.
- W2006301750 hasConcept C177738377 @default.
- W2006301750 hasConcept C202444582 @default.
- W2006301750 hasConcept C2775864247 @default.
- W2006301750 hasConcept C2776570665 @default.
- W2006301750 hasConcept C2777427615 @default.
- W2006301750 hasConcept C2777615928 @default.
- W2006301750 hasConcept C2777865548 @default.
- W2006301750 hasConcept C2779134260 @default.
- W2006301750 hasConcept C2779721402 @default.
- W2006301750 hasConcept C32610206 @default.
- W2006301750 hasConcept C33923547 @default.
- W2006301750 hasConcept C35866371 @default.
- W2006301750 hasConcept C37000724 @default.
- W2006301750 hasConcept C502032728 @default.
- W2006301750 hasConcept C68026918 @default.
- W2006301750 hasConcept C71924100 @default.
- W2006301750 hasConcept C86803240 @default.