Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006302054> ?p ?o ?g. }
- W2006302054 endingPage "1260" @default.
- W2006302054 startingPage "1254" @default.
- W2006302054 abstract "To clarify the mechanism underlying regulation of MUC6 expression, we isolated the 5′ flanking region of the MUC6 gene (5′-MUC6). We determined the transcription start site of the MUC6 gene, and found a TATA box at −35 to −29 bp, a putative NFκB consensus sequence at −173 to −164 bp, and putative Sp family binding sites at −530 to −521 and −847 to −838 bp. The luciferase activity of 5′-MUC6 gradually decreased with deletion of these sites. NFκB inhibitory factor IκB decreased the luciferase activity, and forced expression of NFκB induced MUC6 transcription. An inhibitor of Sp family binding, mithramycin A, suppressed MUC6 transcripts, and Sp1 and Sp3 overexpression up-regulated them. Binding of Sp family members to their putative sites was confirmed by electrophoretic mobility shift assays. Our results suggest that MUC6 transcription is regulated by NFκB and Sp family members." @default.
- W2006302054 created "2016-06-24" @default.
- W2006302054 creator A5004244093 @default.
- W2006302054 creator A5064270578 @default.
- W2006302054 creator A5067475959 @default.
- W2006302054 creator A5067671052 @default.
- W2006302054 date "2005-08-01" @default.
- W2006302054 modified "2023-10-15" @default.
- W2006302054 title "Upregulation of MUC6 mucin gene expression by NFκB and Sp factors" @default.
- W2006302054 cites W1498787975 @default.
- W2006302054 cites W1552115281 @default.
- W2006302054 cites W1701546247 @default.
- W2006302054 cites W1795897263 @default.
- W2006302054 cites W1830287761 @default.
- W2006302054 cites W1859373059 @default.
- W2006302054 cites W1968363114 @default.
- W2006302054 cites W1973931828 @default.
- W2006302054 cites W1974094220 @default.
- W2006302054 cites W1986242902 @default.
- W2006302054 cites W2002000066 @default.
- W2006302054 cites W2017922713 @default.
- W2006302054 cites W2027569621 @default.
- W2006302054 cites W2036477204 @default.
- W2006302054 cites W2038197749 @default.
- W2006302054 cites W2045585687 @default.
- W2006302054 cites W2060615743 @default.
- W2006302054 cites W2060747875 @default.
- W2006302054 cites W2087556585 @default.
- W2006302054 cites W2088446803 @default.
- W2006302054 cites W2089919211 @default.
- W2006302054 cites W2095920344 @default.
- W2006302054 cites W2097702986 @default.
- W2006302054 cites W2104156944 @default.
- W2006302054 cites W2113474033 @default.
- W2006302054 cites W2122283496 @default.
- W2006302054 cites W2133796329 @default.
- W2006302054 cites W2141054539 @default.
- W2006302054 cites W2144626253 @default.
- W2006302054 cites W2144642513 @default.
- W2006302054 cites W2150312232 @default.
- W2006302054 cites W2155664314 @default.
- W2006302054 cites W2161120467 @default.
- W2006302054 cites W2887330449 @default.
- W2006302054 doi "https://doi.org/10.1016/j.bbrc.2005.06.037" @default.
- W2006302054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15979574" @default.
- W2006302054 hasPublicationYear "2005" @default.
- W2006302054 type Work @default.
- W2006302054 sameAs 2006302054 @default.
- W2006302054 citedByCount "23" @default.
- W2006302054 countsByYear W20063020542013 @default.
- W2006302054 countsByYear W20063020542014 @default.
- W2006302054 countsByYear W20063020542017 @default.
- W2006302054 countsByYear W20063020542018 @default.
- W2006302054 countsByYear W20063020542020 @default.
- W2006302054 countsByYear W20063020542022 @default.
- W2006302054 countsByYear W20063020542023 @default.
- W2006302054 crossrefType "journal-article" @default.
- W2006302054 hasAuthorship W2006302054A5004244093 @default.
- W2006302054 hasAuthorship W2006302054A5064270578 @default.
- W2006302054 hasAuthorship W2006302054A5067475959 @default.
- W2006302054 hasAuthorship W2006302054A5067671052 @default.
- W2006302054 hasConcept C104317684 @default.
- W2006302054 hasConcept C107824862 @default.
- W2006302054 hasConcept C111335760 @default.
- W2006302054 hasConcept C127561419 @default.
- W2006302054 hasConcept C138885662 @default.
- W2006302054 hasConcept C150194340 @default.
- W2006302054 hasConcept C153911025 @default.
- W2006302054 hasConcept C179264091 @default.
- W2006302054 hasConcept C179926584 @default.
- W2006302054 hasConcept C183978625 @default.
- W2006302054 hasConcept C41895202 @default.
- W2006302054 hasConcept C54009773 @default.
- W2006302054 hasConcept C54355233 @default.
- W2006302054 hasConcept C55493867 @default.
- W2006302054 hasConcept C86339819 @default.
- W2006302054 hasConcept C86803240 @default.
- W2006302054 hasConceptScore W2006302054C104317684 @default.
- W2006302054 hasConceptScore W2006302054C107824862 @default.
- W2006302054 hasConceptScore W2006302054C111335760 @default.
- W2006302054 hasConceptScore W2006302054C127561419 @default.
- W2006302054 hasConceptScore W2006302054C138885662 @default.
- W2006302054 hasConceptScore W2006302054C150194340 @default.
- W2006302054 hasConceptScore W2006302054C153911025 @default.
- W2006302054 hasConceptScore W2006302054C179264091 @default.
- W2006302054 hasConceptScore W2006302054C179926584 @default.
- W2006302054 hasConceptScore W2006302054C183978625 @default.
- W2006302054 hasConceptScore W2006302054C41895202 @default.
- W2006302054 hasConceptScore W2006302054C54009773 @default.
- W2006302054 hasConceptScore W2006302054C54355233 @default.
- W2006302054 hasConceptScore W2006302054C55493867 @default.
- W2006302054 hasConceptScore W2006302054C86339819 @default.
- W2006302054 hasConceptScore W2006302054C86803240 @default.
- W2006302054 hasFunder F4320320912 @default.
- W2006302054 hasIssue "4" @default.
- W2006302054 hasLocation W20063020541 @default.
- W2006302054 hasLocation W20063020542 @default.
- W2006302054 hasOpenAccess W2006302054 @default.