FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006311924> ?p ?o ?g. }

• W2006311924 endingPage "21" @default.
• W2006311924 startingPage "11" @default.
• W2006311924 abstract "Objectives To ascertain if immunization results in the restoration of responses to recall antigens, in the development of responses to presumed neoantigens, and to identify the virologic and immunologic correlates of these responses in persons with HIV-1 infection. Design and setting Open-label study carried out at three university-affiliated AIDS Clinical Trials Units in the United States. Subjects and methods Thirty-one subjects participating in AIDS Clinical Trials Group Protocol 375 who had received zidovudine, lamivudine, and ritonavir for at least 48 weeks. Subjects were immunized with tetanus toxoid (TT) at entry and with inactivated hepatitis A vaccine (hep A) and keyhole limpet hemocyanin (KLH) at entry and 6 weeks. The development of antibody, lymphocyte proliferative assay (LPA), and delayed-type hypersensitivity (DTH) responses after immunization were monitored. Results The LPA and DTH responses to TT improved in 57 and 68% of participants, respectively; 73 and 65% developed enhanced LPA and DTH responses to KLH. Forty-eight percent of patients developed a four-fold increase in antibody concentration to tetanus. Seventy-three percent of patients without detectable hepatitis A antibodies at baseline developed antibodies after immunization. Eighty-three percent of patients experienced at least a four-fold rise in KLH antibody concentration. Immune activation and viral load predicted poor recall responses and the number of memory CD4+ T-cells predicted good responses to recall antigens. Naïve CD4+ T-cell numbers, decrease in viral load, increases in CD4+ and CD28+ cells, and decreases in immune activation were associated with responses to presumed neoantigens. Conclusions Most HIV-infected patients treated with potent combination antiretrovirals develop responses to recall and presumed neoantigens after immunization. Functional immune restoration in response to immunization is related to control of viral replication, decreased immune activation as well as to both quantitative and qualitative restoration of circulating T- lymphocyte subpopulations." @default.
• W2006311924 created "2016-06-24" @default.
• W2006311924 creator A5000083226 @default.
• W2006311924 creator A5006902332 @default.
• W2006311924 creator A5012821937 @default.
• W2006311924 creator A5016102389 @default.
• W2006311924 creator A5018755609 @default.
• W2006311924 creator A5027607427 @default.
• W2006311924 creator A5029192881 @default.
• W2006311924 creator A5042372640 @default.
• W2006311924 creator A5058715015 @default.
• W2006311924 creator A5061678587 @default.
• W2006311924 creator A5071740265 @default.
• W2006311924 creator A5072899489 @default.
• W2006311924 creator A5075442903 @default.
• W2006311924 creator A5089961811 @default.
• W2006311924 date "2000-01-01" @default.
• W2006311924 modified "2023-10-18" @default.
• W2006311924 title "Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen" @default.
• W2006311924 cites W1965904001 @default.
• W2006311924 cites W1966775255 @default.
• W2006311924 cites W1970622835 @default.
• W2006311924 cites W1973795001 @default.
• W2006311924 cites W1979171231 @default.
• W2006311924 cites W1982448824 @default.
• W2006311924 cites W1983933913 @default.
• W2006311924 cites W1996168633 @default.
• W2006311924 cites W2014533284 @default.
• W2006311924 cites W2014538618 @default.
• W2006311924 cites W2020354584 @default.
• W2006311924 cites W2038515291 @default.
• W2006311924 cites W2038807049 @default.
• W2006311924 cites W2058220670 @default.
• W2006311924 cites W2059745951 @default.
• W2006311924 cites W2068928583 @default.
• W2006311924 cites W2069271307 @default.
• W2006311924 cites W2069523469 @default.
• W2006311924 cites W2073231427 @default.
• W2006311924 cites W2080832675 @default.
• W2006311924 cites W2086375193 @default.
• W2006311924 cites W2088564232 @default.
• W2006311924 cites W2090642065 @default.
• W2006311924 cites W2092285290 @default.
• W2006311924 cites W2110545021 @default.
• W2006311924 cites W2111704944 @default.
• W2006311924 cites W2115898345 @default.
• W2006311924 cites W2121956497 @default.
• W2006311924 cites W2129001976 @default.
• W2006311924 cites W2161961972 @default.
• W2006311924 cites W2167644155 @default.
• W2006311924 cites W2318289184 @default.
• W2006311924 cites W2319153630 @default.
• W2006311924 cites W2324468051 @default.
• W2006311924 cites W2334860476 @default.
• W2006311924 cites W2335496717 @default.
• W2006311924 cites W2339219218 @default.
• W2006311924 doi "https://doi.org/10.1097/00002030-200001070-00002" @default.
• W2006311924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10714563" @default.
• W2006311924 hasPublicationYear "2000" @default.
• W2006311924 type Work @default.
• W2006311924 sameAs 2006311924 @default.
• W2006311924 citedByCount "144" @default.
• W2006311924 countsByYear W20063119242012 @default.
• W2006311924 countsByYear W20063119242013 @default.
• W2006311924 countsByYear W20063119242014 @default.
• W2006311924 countsByYear W20063119242015 @default.
• W2006311924 countsByYear W20063119242016 @default.
• W2006311924 countsByYear W20063119242018 @default.
• W2006311924 countsByYear W20063119242019 @default.
• W2006311924 countsByYear W20063119242020 @default.
• W2006311924 countsByYear W20063119242022 @default.
• W2006311924 countsByYear W20063119242023 @default.
• W2006311924 crossrefType "journal-article" @default.
• W2006311924 hasAuthorship W2006311924A5000083226 @default.
• W2006311924 hasAuthorship W2006311924A5006902332 @default.
• W2006311924 hasAuthorship W2006311924A5012821937 @default.
• W2006311924 hasAuthorship W2006311924A5016102389 @default.
• W2006311924 hasAuthorship W2006311924A5018755609 @default.
• W2006311924 hasAuthorship W2006311924A5027607427 @default.
• W2006311924 hasAuthorship W2006311924A5029192881 @default.
• W2006311924 hasAuthorship W2006311924A5042372640 @default.
• W2006311924 hasAuthorship W2006311924A5058715015 @default.
• W2006311924 hasAuthorship W2006311924A5061678587 @default.
• W2006311924 hasAuthorship W2006311924A5071740265 @default.
• W2006311924 hasAuthorship W2006311924A5072899489 @default.
• W2006311924 hasAuthorship W2006311924A5075442903 @default.
• W2006311924 hasAuthorship W2006311924A5089961811 @default.
• W2006311924 hasConcept C142462285 @default.
• W2006311924 hasConcept C147483822 @default.
• W2006311924 hasConcept C159047783 @default.
• W2006311924 hasConcept C159654299 @default.
• W2006311924 hasConcept C203014093 @default.
• W2006311924 hasConcept C22070199 @default.
• W2006311924 hasConcept C2522874641 @default.
• W2006311924 hasConcept C2776727803 @default.
• W2006311924 hasConcept C2777351567 @default.
• W2006311924 hasConcept C2779841045 @default.
• W2006311924 hasConcept C2780801004 @default.

• next