FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006319239> ?p ?o ?g. }

• W2006319239 endingPage "1336" @default.
• W2006319239 startingPage "1330" @default.
• W2006319239 abstract "It is well-recognized that atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are raised in conditions with ventricular volume and pressure overload. In addition to this established role in left ventricular congestive cardiac failure, there is good evidence that BNP has a diagnostic role in right ventricular (RV) dysfunction and pulmonary arterial hypertension (PAH). For example, BNP levels can be used to differentiate between dyspneic patients with pure respiratory defects and those with RV dysfunction. Studies in patients with PAH have demonstrated significant correlations between BNP levels and mean pulmonary arterial pressure as well as pulmonary vascular resistance. Additionally, BNP has a prognostic role in patients with RV pressure overload and pulmonary hypertension, and it offers a noninvasive test that can be used to guide therapy in patients with PAH. However, although measured plasma proBNP levels are raised in conditions with RV overload, its biological significance is still not well-understood. In this article, we review the general physiologic and potential therapeutic role of natriuretic peptides in respiratory disease, RV dysfunction, and PAH. Furthermore, we assess the various clues toward natriuretic peptide action coming from laboratory studies. ANP and BNP knockout mice develop cardiac fibrosis and hypertrophy. Potentiation of the natriuretic pathway has been shown to reduce cardiac hypertrophy and PAH. This is likely to take place as a result of increased intracellular cyclic guanosine monophosphate levels and subsequent pulmonary vasorelaxant activity. In view of this evidence, there may be a rationale for the therapeutic use of recombinant BNP or neutral endopeptidase inhibitors under conditions of RV dysfunction and PAH." @default.
• W2006319239 created "2016-06-24" @default.
• W2006319239 creator A5012716139 @default.
• W2006319239 creator A5019217625 @default.
• W2006319239 creator A5029251274 @default.
• W2006319239 creator A5059684953 @default.
• W2006319239 creator A5067455165 @default.
• W2006319239 date "2004-10-01" @default.
• W2006319239 modified "2023-10-16" @default.
• W2006319239 title "Natriuretic Peptides, Respiratory Disease, and the Right Heart" @default.
• W2006319239 cites W1759599154 @default.
• W2006319239 cites W1873977532 @default.
• W2006319239 cites W1960406067 @default.
• W2006319239 cites W1968545735 @default.
• W2006319239 cites W1973027577 @default.
• W2006319239 cites W1979978966 @default.
• W2006319239 cites W1988816170 @default.
• W2006319239 cites W1989447605 @default.
• W2006319239 cites W1991157896 @default.
• W2006319239 cites W1994010783 @default.
• W2006319239 cites W1995588722 @default.
• W2006319239 cites W1997143199 @default.
• W2006319239 cites W2001314044 @default.
• W2006319239 cites W2007655614 @default.
• W2006319239 cites W2017554373 @default.
• W2006319239 cites W2021878071 @default.
• W2006319239 cites W2025042121 @default.
• W2006319239 cites W2026470245 @default.
• W2006319239 cites W2027314542 @default.
• W2006319239 cites W2029738901 @default.
• W2006319239 cites W2034484623 @default.
• W2006319239 cites W2036878550 @default.
• W2006319239 cites W2037799674 @default.
• W2006319239 cites W2038638276 @default.
• W2006319239 cites W2043520172 @default.
• W2006319239 cites W2044163607 @default.
• W2006319239 cites W2055927399 @default.
• W2006319239 cites W2058493401 @default.
• W2006319239 cites W2065401884 @default.
• W2006319239 cites W2082409818 @default.
• W2006319239 cites W2085065650 @default.
• W2006319239 cites W2092237225 @default.
• W2006319239 cites W2094945284 @default.
• W2006319239 cites W2098481962 @default.
• W2006319239 cites W2102027030 @default.
• W2006319239 cites W2103751591 @default.
• W2006319239 cites W2108050723 @default.
• W2006319239 cites W2109289052 @default.
• W2006319239 cites W2109488054 @default.
• W2006319239 cites W2109805789 @default.
• W2006319239 cites W2113126233 @default.
• W2006319239 cites W2121199370 @default.
• W2006319239 cites W2121815042 @default.
• W2006319239 cites W2123748337 @default.
• W2006319239 cites W2124250667 @default.
• W2006319239 cites W2126178196 @default.
• W2006319239 cites W2130008346 @default.
• W2006319239 cites W2132106701 @default.
• W2006319239 cites W2133844656 @default.
• W2006319239 cites W2136483429 @default.
• W2006319239 cites W2141811337 @default.
• W2006319239 cites W2142607524 @default.
• W2006319239 cites W2144860656 @default.
• W2006319239 cites W2147883257 @default.
• W2006319239 cites W2150690011 @default.
• W2006319239 cites W2152303208 @default.
• W2006319239 cites W2155400583 @default.
• W2006319239 cites W2159214565 @default.
• W2006319239 cites W2159990281 @default.
• W2006319239 cites W2160056424 @default.
• W2006319239 cites W2167504169 @default.
• W2006319239 cites W2168446154 @default.
• W2006319239 cites W2169429079 @default.
• W2006319239 cites W2170643211 @default.
• W2006319239 cites W2188364927 @default.
• W2006319239 cites W2191613235 @default.
• W2006319239 cites W2252374439 @default.
• W2006319239 cites W2278085417 @default.
• W2006319239 cites W2341785656 @default.
• W2006319239 cites W2403349532 @default.
• W2006319239 cites W2404904530 @default.
• W2006319239 cites W4242028916 @default.
• W2006319239 cites W4253681968 @default.
• W2006319239 doi "https://doi.org/10.1378/chest.126.4.1330" @default.
• W2006319239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15486400" @default.
• W2006319239 hasPublicationYear "2004" @default.
• W2006319239 type Work @default.
• W2006319239 sameAs 2006319239 @default.
• W2006319239 citedByCount "139" @default.
• W2006319239 countsByYear W20063192392012 @default.
• W2006319239 countsByYear W20063192392013 @default.
• W2006319239 countsByYear W20063192392014 @default.
• W2006319239 countsByYear W20063192392015 @default.
• W2006319239 countsByYear W20063192392016 @default.
• W2006319239 countsByYear W20063192392017 @default.
• W2006319239 countsByYear W20063192392018 @default.
• W2006319239 countsByYear W20063192392019 @default.
• W2006319239 countsByYear W20063192392020 @default.

• next