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- W2006319417 abstract "Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of chromosomes obtains at least one crossover, even though the majority of recombination sites yield non-crossovers. A putative regulator of crossing-over is RNF212, which is associated with variation in crossover rates in humans. We show that mouse RNF212 is essential for crossing-over, functioning to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Selective localization of RNF212 to a subset of recombination sites is shown to be a key early step in the crossover designation process. RNF212 acts at these sites to stabilize meiosis-specific recombination factors, including the MutSγ complex (MSH4-MSH5). We infer that selective stabilization of key recombination proteins is a fundamental feature of meiotic crossover control. Haploinsufficiency indicates that RNF212 is a limiting factor for crossover control and raises the possibility that human alleles may alter the amount or stability of RNF212 and be risk factors for aneuploid conditions." @default.
- W2006319417 created "2016-06-24" @default.
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- W2006319417 creator A5056343391 @default.
- W2006319417 creator A5065765257 @default.
- W2006319417 creator A5084129299 @default.
- W2006319417 date "2013-02-10" @default.
- W2006319417 modified "2023-10-05" @default.
- W2006319417 title "RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis" @default.
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