Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006322641> ?p ?o ?g. }
- W2006322641 endingPage "e1001911" @default.
- W2006322641 startingPage "e1001911" @default.
- W2006322641 abstract "Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport, including Vitamin K and Coenzyme Q. In humans, missense mutations to the protein UbiA prenyltransferase domain-containing 1 (UBIAD1) are responsible for Schnyder crystalline corneal dystrophy, which is a genetic disease that causes blindness. Mechanistic understanding of this family of enzymes has been hampered by a lack of three-dimensional structures. We have solved structures of a UBIAD1 homolog from Archaeoglobus fulgidus, AfUbiA, in an unliganded form and bound to Mg2+ and two different isoprenyl diphosphates. Functional assays on MenA, a UbiA family member from E. coli, verified the importance of residues involved in Mg2+ and substrate binding. The structural and functional studies led us to propose a mechanism for the prenyl transfer reaction. Disease-causing mutations in UBIAD1 are clustered around the active site in AfUbiA, suggesting the mechanism of catalysis is conserved between the two homologs." @default.
- W2006322641 created "2016-06-24" @default.
- W2006322641 creator A5005931510 @default.
- W2006322641 creator A5056870218 @default.
- W2006322641 creator A5067033957 @default.
- W2006322641 creator A5070412927 @default.
- W2006322641 creator A5071657898 @default.
- W2006322641 creator A5084470895 @default.
- W2006322641 date "2014-07-22" @default.
- W2006322641 modified "2023-10-16" @default.
- W2006322641 title "Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1" @default.
- W2006322641 cites W1481147497 @default.
- W2006322641 cites W1520912904 @default.
- W2006322641 cites W1534973403 @default.
- W2006322641 cites W1539796472 @default.
- W2006322641 cites W1545800501 @default.
- W2006322641 cites W1576943688 @default.
- W2006322641 cites W1585975789 @default.
- W2006322641 cites W1970757070 @default.
- W2006322641 cites W1982217267 @default.
- W2006322641 cites W1993392786 @default.
- W2006322641 cites W2000558508 @default.
- W2006322641 cites W2015106370 @default.
- W2006322641 cites W2017498808 @default.
- W2006322641 cites W2018621238 @default.
- W2006322641 cites W2030489986 @default.
- W2006322641 cites W2030724157 @default.
- W2006322641 cites W2041612214 @default.
- W2006322641 cites W2042264135 @default.
- W2006322641 cites W2047055477 @default.
- W2006322641 cites W2050947103 @default.
- W2006322641 cites W2054000425 @default.
- W2006322641 cites W2058390644 @default.
- W2006322641 cites W2058658881 @default.
- W2006322641 cites W2062507791 @default.
- W2006322641 cites W2065350912 @default.
- W2006322641 cites W2067541286 @default.
- W2006322641 cites W2073001174 @default.
- W2006322641 cites W2092214789 @default.
- W2006322641 cites W2098959116 @default.
- W2006322641 cites W2103378962 @default.
- W2006322641 cites W2105452951 @default.
- W2006322641 cites W2106717331 @default.
- W2006322641 cites W2107527796 @default.
- W2006322641 cites W2124026197 @default.
- W2006322641 cites W2125903258 @default.
- W2006322641 cites W2128179467 @default.
- W2006322641 cites W2132530208 @default.
- W2006322641 cites W2138888637 @default.
- W2006322641 cites W2139233932 @default.
- W2006322641 cites W2139388109 @default.
- W2006322641 cites W2145604196 @default.
- W2006322641 cites W2149852370 @default.
- W2006322641 cites W2157728632 @default.
- W2006322641 cites W2166638083 @default.
- W2006322641 cites W2168621448 @default.
- W2006322641 cites W2180229411 @default.
- W2006322641 cites W4254886113 @default.
- W2006322641 cites W4320301318 @default.
- W2006322641 doi "https://doi.org/10.1371/journal.pbio.1001911" @default.
- W2006322641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4106721" @default.
- W2006322641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25051182" @default.
- W2006322641 hasPublicationYear "2014" @default.
- W2006322641 type Work @default.
- W2006322641 sameAs 2006322641 @default.
- W2006322641 citedByCount "83" @default.
- W2006322641 countsByYear W20063226412014 @default.
- W2006322641 countsByYear W20063226412015 @default.
- W2006322641 countsByYear W20063226412016 @default.
- W2006322641 countsByYear W20063226412017 @default.
- W2006322641 countsByYear W20063226412018 @default.
- W2006322641 countsByYear W20063226412019 @default.
- W2006322641 countsByYear W20063226412020 @default.
- W2006322641 countsByYear W20063226412021 @default.
- W2006322641 countsByYear W20063226412022 @default.
- W2006322641 countsByYear W20063226412023 @default.
- W2006322641 crossrefType "journal-article" @default.
- W2006322641 hasAuthorship W2006322641A5005931510 @default.
- W2006322641 hasAuthorship W2006322641A5056870218 @default.
- W2006322641 hasAuthorship W2006322641A5067033957 @default.
- W2006322641 hasAuthorship W2006322641A5070412927 @default.
- W2006322641 hasAuthorship W2006322641A5071657898 @default.
- W2006322641 hasAuthorship W2006322641A5084470895 @default.
- W2006322641 hasBestOaLocation W20063226411 @default.
- W2006322641 hasConcept C104317684 @default.
- W2006322641 hasConcept C161624437 @default.
- W2006322641 hasConcept C181199279 @default.
- W2006322641 hasConcept C2776085463 @default.
- W2006322641 hasConcept C501734568 @default.
- W2006322641 hasConcept C55493867 @default.
- W2006322641 hasConcept C57790582 @default.
- W2006322641 hasConcept C75563809 @default.
- W2006322641 hasConcept C86803240 @default.
- W2006322641 hasConceptScore W2006322641C104317684 @default.
- W2006322641 hasConceptScore W2006322641C161624437 @default.
- W2006322641 hasConceptScore W2006322641C181199279 @default.
- W2006322641 hasConceptScore W2006322641C2776085463 @default.
- W2006322641 hasConceptScore W2006322641C501734568 @default.