FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006325944> ?p ?o ?g. }

• W2006325944 endingPage "43" @default.
• W2006325944 startingPage "23" @default.
• W2006325944 abstract "Clostridium perfringens is an important pathogen in veterinary and medical fields. Diseases caused by this organism are in many cases life threatening or fatal. At the same time, it is part of the ecological community of the intestinal tract of man and animals. Virulence in this species is not fully understood and it does seem that there is erratic distribution of the toxin/enzyme genes within C. perfringens population. We used the recently developed multiple-locus variable-number tandem repeat analysis (MLVA) scheme to investigate the evolution of virulence and population structure of this species. Analysis of the phylogenetic signal indicates that acquisition of the major toxin genes as well as other plasmidborne toxin genes is a recent evolutionary event and their maintenance is essentially a function of the selective advantage they confer in certain niches under different conditions. In addition, it indicates the ability of virulent strains to cause disease in different host species. More interestingly, there is evidence that certain normal flora strains are virulent when they gain access to a different host species. Analysis of the population structure indicates that recombination events are the major tool that shapes the population and this panmixia is interrupted by frequent clonal expansion that mostly corresponds to disease processes. The signature of positive selection was detected in alpha toxin gene, suggesting the possibility of adaptive alleles on the other chromosomally encoded determinants. Finally, C. perfringens proved to have a dynamic population and availability of more genome sequences and use of comparative proteomics and animal modeling would provide more insight into the virulence of this organism." @default.
• W2006325944 created "2016-06-24" @default.
• W2006325944 creator A5033476782 @default.
• W2006325944 creator A5044564056 @default.
• W2006325944 date "2006-02-01" @default.
• W2006325944 modified "2023-10-16" @default.
• W2006325944 title "Clostridium perfringens: Insight into virulence evolution and population structure" @default.
• W2006325944 cites W1486649516 @default.
• W2006325944 cites W1865902430 @default.
• W2006325944 cites W1895949598 @default.
• W2006325944 cites W1904815041 @default.
• W2006325944 cites W1964063724 @default.
• W2006325944 cites W1968077150 @default.
• W2006325944 cites W1968146772 @default.
• W2006325944 cites W1973033234 @default.
• W2006325944 cites W1981341928 @default.
• W2006325944 cites W1982415473 @default.
• W2006325944 cites W1982603712 @default.
• W2006325944 cites W1984561439 @default.
• W2006325944 cites W1986087546 @default.
• W2006325944 cites W1987128306 @default.
• W2006325944 cites W1998019829 @default.
• W2006325944 cites W1998336844 @default.
• W2006325944 cites W2004690000 @default.
• W2006325944 cites W2008630448 @default.
• W2006325944 cites W2012593448 @default.
• W2006325944 cites W2013941127 @default.
• W2006325944 cites W2015357321 @default.
• W2006325944 cites W2024239836 @default.
• W2006325944 cites W2027830088 @default.
• W2006325944 cites W2028470290 @default.
• W2006325944 cites W2032470595 @default.
• W2006325944 cites W2035708099 @default.
• W2006325944 cites W2036039378 @default.
• W2006325944 cites W2042855579 @default.
• W2006325944 cites W2053279796 @default.
• W2006325944 cites W2054850445 @default.
• W2006325944 cites W2057824725 @default.
• W2006325944 cites W2062886408 @default.
• W2006325944 cites W2065280951 @default.
• W2006325944 cites W2069683041 @default.
• W2006325944 cites W2077643492 @default.
• W2006325944 cites W2087762882 @default.
• W2006325944 cites W2093483191 @default.
• W2006325944 cites W2094013330 @default.
• W2006325944 cites W2095116102 @default.
• W2006325944 cites W2095655760 @default.
• W2006325944 cites W2103347521 @default.
• W2006325944 cites W2104606186 @default.
• W2006325944 cites W2106882534 @default.
• W2006325944 cites W2111159643 @default.
• W2006325944 cites W2112704704 @default.
• W2006325944 cites W2114196688 @default.
• W2006325944 cites W2114671415 @default.
• W2006325944 cites W2116598668 @default.
• W2006325944 cites W2116754039 @default.
• W2006325944 cites W2117435951 @default.
• W2006325944 cites W2119530493 @default.
• W2006325944 cites W2120268627 @default.
• W2006325944 cites W2121857159 @default.
• W2006325944 cites W2122999080 @default.
• W2006325944 cites W2130222655 @default.
• W2006325944 cites W2131106132 @default.
• W2006325944 cites W2135421042 @default.
• W2006325944 cites W2135967870 @default.
• W2006325944 cites W2138004396 @default.
• W2006325944 cites W2140059688 @default.
• W2006325944 cites W2141849449 @default.
• W2006325944 cites W2141998772 @default.
• W2006325944 cites W2147834333 @default.
• W2006325944 cites W2149652290 @default.
• W2006325944 cites W2151371624 @default.
• W2006325944 cites W2156080241 @default.
• W2006325944 cites W2157804398 @default.
• W2006325944 cites W2163778952 @default.
• W2006325944 cites W2170093840 @default.
• W2006325944 cites W2322567605 @default.
• W2006325944 cites W4236356747 @default.
• W2006325944 doi "https://doi.org/10.1016/j.anaerobe.2005.10.002" @default.
• W2006325944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16701609" @default.
• W2006325944 hasPublicationYear "2006" @default.
• W2006325944 type Work @default.
• W2006325944 sameAs 2006325944 @default.
• W2006325944 citedByCount "91" @default.
• W2006325944 countsByYear W20063259442012 @default.
• W2006325944 countsByYear W20063259442013 @default.
• W2006325944 countsByYear W20063259442014 @default.
• W2006325944 countsByYear W20063259442015 @default.
• W2006325944 countsByYear W20063259442016 @default.
• W2006325944 countsByYear W20063259442017 @default.
• W2006325944 countsByYear W20063259442018 @default.
• W2006325944 countsByYear W20063259442019 @default.
• W2006325944 countsByYear W20063259442020 @default.
• W2006325944 countsByYear W20063259442021 @default.
• W2006325944 countsByYear W20063259442022 @default.
• W2006325944 countsByYear W20063259442023 @default.
• W2006325944 crossrefType "journal-article" @default.
• W2006325944 hasAuthorship W2006325944A5033476782 @default.

• next