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- W2006333782 abstract "Objective To develop Thai-specific medians of serum pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotropin (hCG) levels during the first trimester of pregnancy and to compare these values to a Caucasian-specific model for the detection of fetal Down syndrome. Methods Serum concentrations of PAPP-A and free β-hCG were measured during the first trimester in a group of 2339 Thai women undergoing normal singleton pregnancies. Results Thai reference ranges of PAPP-A and free β-hCG were established by gestational age (70–98 days). The equation of best fit for PAPP-A was: predicted median PAPP-A level = 28.767 – 0.781 × (gestational age in days) + 0.006 × (gestational age in days)2; r = 0.986. The equation of best fit for free β-hCG was: predicted median free β-hCG level = 465.332 × 10(–0.024 × gestational age in days); r = 0.881. Weight-corrected models were also derived for each biomarker. The Thai-specific reference ranges gave higher positive screening rates than the Caucasian-specific model, even after weight correction (5.1% versus 4.0%). The Thai-specific models were validated in an independent group of 302 pregnant women. Conclusion Ethnic group-specific medians for PAPP-A and free β-hCG should be incorporated during first-trimester screening for fetal Down syndrome." @default.
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- W2006333782 date "2012-02-25" @default.
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- W2006333782 title "Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women" @default.
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- W2006333782 doi "https://doi.org/10.1016/j.ijgo.2011.11.026" @default.
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