FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006335846> ?p ?o ?g. }

• W2006335846 abstract "TEM1/endosialin is an emerging microvascular marker of tumor angiogenesis. We characterized the expression pattern of TEM1/endosialin in astrocytic and metastatic brain tumors and investigated its role as a therapeutic target in human endothelial cells and mouse xenograft models. In situ hybridization (ISH), immunohistochemistry (IH) and immunofluorescence (IF) were used to localize TEM1/endosialin expression in grade II-IV astrocytomas and metastatic brain tumors on tissue microarrays. Changes in TEM1/endosialin expression in response to pro-angiogenic conditions were assessed in human endothelial cells grown in vitro. Intracranial U87MG glioblastoma (GBM) xenografts were analyzed in nude TEM1/endosialin knockout (KO) and wildtype (WT) mice. TEM1/endosialin was upregulated in primary and metastatic human brain tumors, where it localized primarily to the tumor vasculature and a subset of tumor stromal cells. Analysis of 275 arrayed grade II-IV astrocytomas demonstrated TEM1/endosialin expression in 79% of tumors. Robust TEM1/endosialin expression occurred in 31% of glioblastomas (grade IV astroctyomas). TEM1/endosialin expression was inversely correlated with patient age. TEM1/endosialin showed limited co-localization with CD31, αSMA and fibronectin in clinical specimens. In vitro, TEM1/endosialin was upregulated in human endothelial cells cultured in matrigel. Vascular Tem1/endosialin was induced in intracranial U87MG GBM xenografts grown in mice. Tem1/endosialin KO vs WT mice demonstrated equivalent survival and tumor growth when implanted with intracranial GBM xenografts, although Tem1/endosialin KO tumors were significantly more vascular than the WT counterparts. TEM1/endosialin was induced in the vasculature of high-grade brain tumors where its expression was inversely correlated with patient age. Although lack of TEM1/endosialin did not suppress growth of intracranial GBM xenografts, it did increase tumor vascularity. The cellular localization of TEM1/endosialin and its expression profile in primary and metastatic brain tumors support efforts to therapeutically target this protein, potentially via antibody mediated drug delivery strategies." @default.
• W2006335846 created "2016-06-24" @default.
• W2006335846 creator A5010219978 @default.
• W2006335846 creator A5013214842 @default.
• W2006335846 creator A5023363049 @default.
• W2006335846 creator A5025299587 @default.
• W2006335846 creator A5046479135 @default.
• W2006335846 creator A5077727552 @default.
• W2006335846 creator A5081257961 @default.
• W2006335846 creator A5084998801 @default.
• W2006335846 creator A5085150194 @default.
• W2006335846 creator A5088768449 @default.
• W2006335846 date "2009-11-30" @default.
• W2006335846 modified "2023-10-12" @default.
• W2006335846 title "Characterization of TEM1/endosialinin human and murine brain tumors" @default.
• W2006335846 cites W1510479634 @default.
• W2006335846 cites W1981752409 @default.
• W2006335846 cites W2013010261 @default.
• W2006335846 cites W2016247489 @default.
• W2006335846 cites W2019096329 @default.
• W2006335846 cites W2019541940 @default.
• W2006335846 cites W2020313726 @default.
• W2006335846 cites W2025555160 @default.
• W2006335846 cites W2026217376 @default.
• W2006335846 cites W2050172553 @default.
• W2006335846 cites W2063405392 @default.
• W2006335846 cites W2076022365 @default.
• W2006335846 cites W2079410628 @default.
• W2006335846 cites W2084054324 @default.
• W2006335846 cites W2086818932 @default.
• W2006335846 cites W2087739218 @default.
• W2006335846 cites W2092831567 @default.
• W2006335846 cites W2101037339 @default.
• W2006335846 cites W2103328690 @default.
• W2006335846 cites W2117013761 @default.
• W2006335846 cites W2122999961 @default.
• W2006335846 cites W2127940510 @default.
• W2006335846 cites W2130055760 @default.
• W2006335846 cites W2138814678 @default.
• W2006335846 cites W2139646490 @default.
• W2006335846 cites W2151794458 @default.
• W2006335846 cites W2152474871 @default.
• W2006335846 cites W2154881868 @default.
• W2006335846 cites W2166592301 @default.
• W2006335846 cites W2416129203 @default.
• W2006335846 cites W4253705647 @default.
• W2006335846 doi "https://doi.org/10.1186/1471-2407-9-417" @default.
• W2006335846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2793264" @default.
• W2006335846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19948061" @default.
• W2006335846 hasPublicationYear "2009" @default.
• W2006335846 type Work @default.
• W2006335846 sameAs 2006335846 @default.
• W2006335846 citedByCount "40" @default.
• W2006335846 countsByYear W20063358462012 @default.
• W2006335846 countsByYear W20063358462014 @default.
• W2006335846 countsByYear W20063358462015 @default.
• W2006335846 countsByYear W20063358462016 @default.
• W2006335846 countsByYear W20063358462017 @default.
• W2006335846 countsByYear W20063358462018 @default.
• W2006335846 countsByYear W20063358462019 @default.
• W2006335846 countsByYear W20063358462020 @default.
• W2006335846 countsByYear W20063358462021 @default.
• W2006335846 countsByYear W20063358462022 @default.
• W2006335846 countsByYear W20063358462023 @default.
• W2006335846 crossrefType "journal-article" @default.
• W2006335846 hasAuthorship W2006335846A5010219978 @default.
• W2006335846 hasAuthorship W2006335846A5013214842 @default.
• W2006335846 hasAuthorship W2006335846A5023363049 @default.
• W2006335846 hasAuthorship W2006335846A5025299587 @default.
• W2006335846 hasAuthorship W2006335846A5046479135 @default.
• W2006335846 hasAuthorship W2006335846A5077727552 @default.
• W2006335846 hasAuthorship W2006335846A5081257961 @default.
• W2006335846 hasAuthorship W2006335846A5084998801 @default.
• W2006335846 hasAuthorship W2006335846A5085150194 @default.
• W2006335846 hasAuthorship W2006335846A5088768449 @default.
• W2006335846 hasBestOaLocation W20063358461 @default.
• W2006335846 hasConcept C142724271 @default.
• W2006335846 hasConcept C2778939058 @default.
• W2006335846 hasConcept C2780394083 @default.
• W2006335846 hasConcept C502942594 @default.
• W2006335846 hasConcept C71924100 @default.
• W2006335846 hasConceptScore W2006335846C142724271 @default.
• W2006335846 hasConceptScore W2006335846C2778939058 @default.
• W2006335846 hasConceptScore W2006335846C2780394083 @default.
• W2006335846 hasConceptScore W2006335846C502942594 @default.
• W2006335846 hasConceptScore W2006335846C71924100 @default.
• W2006335846 hasIssue "1" @default.
• W2006335846 hasLocation W20063358461 @default.
• W2006335846 hasLocation W20063358462 @default.
• W2006335846 hasLocation W20063358463 @default.
• W2006335846 hasLocation W20063358464 @default.
• W2006335846 hasLocation W20063358465 @default.
• W2006335846 hasOpenAccess W2006335846 @default.
• W2006335846 hasPrimaryLocation W20063358461 @default.
• W2006335846 hasRelatedWork W1964427367 @default.
• W2006335846 hasRelatedWork W1980885235 @default.
• W2006335846 hasRelatedWork W1995515455 @default.
• W2006335846 hasRelatedWork W2080531066 @default.
• W2006335846 hasRelatedWork W2397565192 @default.
• W2006335846 hasRelatedWork W2748952813 @default.

• next