FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006340149> ?p ?o ?g. }

• W2006340149 endingPage "1784" @default.
• W2006340149 startingPage "1775" @default.
• W2006340149 abstract "Signaling of single photons in rod photoreceptors decreases the concentration of the second messenger, cyclic GMP (cGMP), causing closure of cGMP-sensitive channels located in the plasma membrane. Whether the spatiotemporal profiles of the fall in cGMP are narrow and deep, or broad and shallow, has important consequences for the amplification and the fidelity of signaling. The factors that determine the cGMP profiles include the diffusion coefficient for cGMP, the spontaneous rate of cGMP hydrolysis, and the rate of cGMP synthesis, which is powerfully regulated by calcium feedback mechanisms. Here, using suction electrodes to record light-dependent changes in cGMP-activated current in living mouse rods lacking calcium feedback, we have determined the rate constant of spontaneous cGMP hydrolysis and the longitudinal cGMP diffusion coefficient. These measurements result in a fully constrained spatiotemporal model of phototransduction, which we used to determine the effect of feedback to cGMP synthesis in spatially constricting the fall of cGMP during the single-photon response of normal rods. We find that the spatiotemporal cGMP profiles during the single-photon response are optimized for maximal amplification and preservation of signal linearity, effectively operating within an axial signaling domain of ∼2 μm." @default.
• W2006340149 created "2016-06-24" @default.
• W2006340149 creator A5007654156 @default.
• W2006340149 creator A5037070406 @default.
• W2006340149 creator A5066376581 @default.
• W2006340149 date "2012-04-01" @default.
• W2006340149 modified "2023-10-17" @default.
• W2006340149 title "Spatiotemporal cGMP Dynamics in Living Mouse Rods" @default.
• W2006340149 cites W1583347069 @default.
• W2006340149 cites W1972165328 @default.
• W2006340149 cites W1973121755 @default.
• W2006340149 cites W1975994829 @default.
• W2006340149 cites W1976721822 @default.
• W2006340149 cites W1978281876 @default.
• W2006340149 cites W1987183910 @default.
• W2006340149 cites W1988285787 @default.
• W2006340149 cites W1989433038 @default.
• W2006340149 cites W1990968908 @default.
• W2006340149 cites W1997328693 @default.
• W2006340149 cites W1998029597 @default.
• W2006340149 cites W1999179844 @default.
• W2006340149 cites W2004196814 @default.
• W2006340149 cites W2009259360 @default.
• W2006340149 cites W2010375302 @default.
• W2006340149 cites W2010415181 @default.
• W2006340149 cites W2016637218 @default.
• W2006340149 cites W2016957498 @default.
• W2006340149 cites W2023343036 @default.
• W2006340149 cites W2023471335 @default.
• W2006340149 cites W2024664315 @default.
• W2006340149 cites W2039323873 @default.
• W2006340149 cites W2043386957 @default.
• W2006340149 cites W2044092807 @default.
• W2006340149 cites W2047057288 @default.
• W2006340149 cites W2054950142 @default.
• W2006340149 cites W2074623055 @default.
• W2006340149 cites W2075235335 @default.
• W2006340149 cites W2077417840 @default.
• W2006340149 cites W2093475470 @default.
• W2006340149 cites W2111855919 @default.
• W2006340149 cites W2114266738 @default.
• W2006340149 cites W2123786825 @default.
• W2006340149 cites W2134950472 @default.
• W2006340149 cites W2138150058 @default.
• W2006340149 cites W2142913230 @default.
• W2006340149 cites W2148658703 @default.
• W2006340149 cites W2159578432 @default.
• W2006340149 cites W2161318689 @default.
• W2006340149 cites W2166556622 @default.
• W2006340149 cites W97593416 @default.
• W2006340149 doi "https://doi.org/10.1016/j.bpj.2012.03.035" @default.
• W2006340149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3328695" @default.
• W2006340149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22768933" @default.
• W2006340149 hasPublicationYear "2012" @default.
• W2006340149 type Work @default.
• W2006340149 sameAs 2006340149 @default.
• W2006340149 citedByCount "40" @default.
• W2006340149 countsByYear W20063401492012 @default.
• W2006340149 countsByYear W20063401492013 @default.
• W2006340149 countsByYear W20063401492014 @default.
• W2006340149 countsByYear W20063401492015 @default.
• W2006340149 countsByYear W20063401492016 @default.
• W2006340149 countsByYear W20063401492017 @default.
• W2006340149 countsByYear W20063401492018 @default.
• W2006340149 countsByYear W20063401492019 @default.
• W2006340149 countsByYear W20063401492020 @default.
• W2006340149 countsByYear W20063401492021 @default.
• W2006340149 countsByYear W20063401492022 @default.
• W2006340149 countsByYear W20063401492023 @default.
• W2006340149 crossrefType "journal-article" @default.
• W2006340149 hasAuthorship W2006340149A5007654156 @default.
• W2006340149 hasAuthorship W2006340149A5037070406 @default.
• W2006340149 hasAuthorship W2006340149A5066376581 @default.
• W2006340149 hasBestOaLocation W20063401491 @default.
• W2006340149 hasConcept C121332964 @default.
• W2006340149 hasConcept C12554922 @default.
• W2006340149 hasConcept C131667965 @default.
• W2006340149 hasConcept C145912823 @default.
• W2006340149 hasConcept C163235415 @default.
• W2006340149 hasConcept C165801399 @default.
• W2006340149 hasConcept C181199279 @default.
• W2006340149 hasConcept C185592680 @default.
• W2006340149 hasConcept C24890656 @default.
• W2006340149 hasConcept C2780827179 @default.
• W2006340149 hasConcept C3020139451 @default.
• W2006340149 hasConcept C55493867 @default.
• W2006340149 hasConcept C62520636 @default.
• W2006340149 hasConcept C69357855 @default.
• W2006340149 hasConcept C79879829 @default.
• W2006340149 hasConcept C86803240 @default.
• W2006340149 hasConcept C93586867 @default.
• W2006340149 hasConcept C97355855 @default.
• W2006340149 hasConceptScore W2006340149C121332964 @default.
• W2006340149 hasConceptScore W2006340149C12554922 @default.
• W2006340149 hasConceptScore W2006340149C131667965 @default.
• W2006340149 hasConceptScore W2006340149C145912823 @default.
• W2006340149 hasConceptScore W2006340149C163235415 @default.
• W2006340149 hasConceptScore W2006340149C165801399 @default.

• next