FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006347148> ?p ?o ?g. }

• W2006347148 endingPage "1515" @default.
• W2006347148 startingPage "1510" @default.
• W2006347148 abstract "The immunoregulatory effect of Artin M and jacalin from extract of Artocarpus integrifolia seeds (jack extract) against infection with Candida albicans was investigated. Swiss mice received jack extract containing 500 μg protein/ml PBS intraperitoneally (i.p.) or PBS alone and after 72 h were infected i.p. with C. albicans CR15 (10(7)) and sacrificed after 30 min, 2, 6, 24, and 72 h. ELISA analysis revealed that in jack extract-treated mice IFN-γ was predominantly produced versus IL-10 in control mice. These results suggest that jack extract induced a protective immune response, since C. albicans clearance was complete at 72 h postinfection. Jack extract presents two lectins (Artin M and jacalin) with distinct biological properties. Artin M was able to induce IL-12 production by macrophages. Also, Artin M in different concentrations, associated with jacalin or in jack extract induced both IFN-γ and IL-17 production. As a consequence, phagocytic and candidacidal activity increased significantly. Alanine aminotransferase activity (ALT) was used as parameter for damage of the liver. The activity of ALT correlated with inoculum size that increased significantly in control group, however, mice pretreated with jack extract 3 days before infection presented normal ALT. Mice pretreated with jack extract that received a lethal inoculum of Candida presented 90% survival versus 20% among controls or mice pretreated with jacalin. Thus, the results suggest that Artin M by itself, associated with jacalin or present in jack extract is able to induce protective Th1 and Th17 immune responses against Candida albicans infection." @default.
• W2006347148 created "2016-06-24" @default.
• W2006347148 creator A5029645591 @default.
• W2006347148 creator A5035901432 @default.
• W2006347148 creator A5057548266 @default.
• W2006347148 creator A5072543284 @default.
• W2006347148 creator A5084550827 @default.
• W2006347148 date "2011-10-01" @default.
• W2006347148 modified "2023-09-27" @default.
• W2006347148 title "Protective effect of Artin M from extract of Artocarpus integrifolia seeds by Th1 and Th17 immune response on the course of infection by Candida albicans" @default.
• W2006347148 cites W1499921224 @default.
• W2006347148 cites W1574685364 @default.
• W2006347148 cites W1606562654 @default.
• W2006347148 cites W1967984244 @default.
• W2006347148 cites W1983003545 @default.
• W2006347148 cites W1993800351 @default.
• W2006347148 cites W1994086667 @default.
• W2006347148 cites W2005942700 @default.
• W2006347148 cites W2011303892 @default.
• W2006347148 cites W2029713274 @default.
• W2006347148 cites W2040129238 @default.
• W2006347148 cites W2047022003 @default.
• W2006347148 cites W2063215530 @default.
• W2006347148 cites W2078178431 @default.
• W2006347148 cites W2083968901 @default.
• W2006347148 cites W2085373613 @default.
• W2006347148 cites W2088999662 @default.
• W2006347148 cites W2089380363 @default.
• W2006347148 cites W2105431096 @default.
• W2006347148 cites W2112133235 @default.
• W2006347148 cites W2118488893 @default.
• W2006347148 cites W2129612572 @default.
• W2006347148 cites W2141563676 @default.
• W2006347148 cites W2154200606 @default.
• W2006347148 cites W2164028234 @default.
• W2006347148 cites W2164275517 @default.
• W2006347148 cites W2164826387 @default.
• W2006347148 cites W2170732078 @default.
• W2006347148 cites W2408258077 @default.
• W2006347148 cites W4211087629 @default.
• W2006347148 cites W4293247451 @default.
• W2006347148 cites W4313310013 @default.
• W2006347148 doi "https://doi.org/10.1016/j.intimp.2011.05.005" @default.
• W2006347148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21609786" @default.
• W2006347148 hasPublicationYear "2011" @default.
• W2006347148 type Work @default.
• W2006347148 sameAs 2006347148 @default.
• W2006347148 citedByCount "26" @default.
• W2006347148 countsByYear W20063471482012 @default.
• W2006347148 countsByYear W20063471482013 @default.
• W2006347148 countsByYear W20063471482014 @default.
• W2006347148 countsByYear W20063471482015 @default.
• W2006347148 countsByYear W20063471482016 @default.
• W2006347148 countsByYear W20063471482017 @default.
• W2006347148 countsByYear W20063471482018 @default.
• W2006347148 countsByYear W20063471482019 @default.
• W2006347148 countsByYear W20063471482020 @default.
• W2006347148 countsByYear W20063471482021 @default.
• W2006347148 countsByYear W20063471482022 @default.
• W2006347148 crossrefType "journal-article" @default.
• W2006347148 hasAuthorship W2006347148A5029645591 @default.
• W2006347148 hasAuthorship W2006347148A5035901432 @default.
• W2006347148 hasAuthorship W2006347148A5057548266 @default.
• W2006347148 hasAuthorship W2006347148A5072543284 @default.
• W2006347148 hasAuthorship W2006347148A5084550827 @default.
• W2006347148 hasBestOaLocation W20063471481 @default.
• W2006347148 hasConcept C145081991 @default.
• W2006347148 hasConcept C185592680 @default.
• W2006347148 hasConcept C203014093 @default.
• W2006347148 hasConcept C2776600866 @default.
• W2006347148 hasConcept C2777674797 @default.
• W2006347148 hasConcept C2780758401 @default.
• W2006347148 hasConcept C2780917455 @default.
• W2006347148 hasConcept C59822182 @default.
• W2006347148 hasConcept C86803240 @default.
• W2006347148 hasConcept C8891405 @default.
• W2006347148 hasConcept C89423630 @default.
• W2006347148 hasConceptScore W2006347148C145081991 @default.
• W2006347148 hasConceptScore W2006347148C185592680 @default.
• W2006347148 hasConceptScore W2006347148C203014093 @default.
• W2006347148 hasConceptScore W2006347148C2776600866 @default.
• W2006347148 hasConceptScore W2006347148C2777674797 @default.
• W2006347148 hasConceptScore W2006347148C2780758401 @default.
• W2006347148 hasConceptScore W2006347148C2780917455 @default.
• W2006347148 hasConceptScore W2006347148C59822182 @default.
• W2006347148 hasConceptScore W2006347148C86803240 @default.
• W2006347148 hasConceptScore W2006347148C8891405 @default.
• W2006347148 hasConceptScore W2006347148C89423630 @default.
• W2006347148 hasFunder F4320321091 @default.
• W2006347148 hasFunder F4320322025 @default.
• W2006347148 hasFunder F4320322772 @default.
• W2006347148 hasIssue "10" @default.
• W2006347148 hasLocation W20063471481 @default.
• W2006347148 hasLocation W20063471482 @default.
• W2006347148 hasOpenAccess W2006347148 @default.
• W2006347148 hasPrimaryLocation W20063471481 @default.
• W2006347148 hasRelatedWork W2006347148 @default.
• W2006347148 hasRelatedWork W2128291007 @default.

• next