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- W2006350083 endingPage "745" @default.
- W2006350083 startingPage "732" @default.
- W2006350083 abstract "In less than a decade after discovery, RNA interference-mediated gene silencing is already being tested as potential therapy in clinical trials for a number of diseases. Lentiviral vectors provide a means to express short hairpin RNA (shRNA) to induce stable and long-term gene silencing in both dividing and non-dividing cells and thus, are being intensively investigated for this purpose. However, induction of long-term shRNA expression can also cause toxicities by inducing off-target effects and interference with the endogenous micro-RNA (miRNA) pathway that regulates cellular gene expression. Recently, several advances have been made in the shRNA vector design to mimic cellular miRNA processing and to express multiplex siRNAs in a tightly regulated and reversible manner to overcome toxicities. In this review we describe some of these advances, focusing on the progress made in the development of lentiviral shRNA delivery strategies to combat viral infections." @default.
- W2006350083 created "2016-06-24" @default.
- W2006350083 creator A5031120884 @default.
- W2006350083 creator A5076586650 @default.
- W2006350083 creator A5077047943 @default.
- W2006350083 creator A5088016967 @default.
- W2006350083 date "2009-07-01" @default.
- W2006350083 modified "2023-10-10" @default.
- W2006350083 title "Lentiviral delivery of short hairpin RNAs" @default.
- W2006350083 cites W144423133 @default.
- W2006350083 cites W1502501099 @default.
- W2006350083 cites W1527322157 @default.
- W2006350083 cites W1585973412 @default.
- W2006350083 cites W1611419331 @default.
- W2006350083 cites W173889686 @default.
- W2006350083 cites W1835972708 @default.
- W2006350083 cites W1964900383 @default.
- W2006350083 cites W1965881928 @default.
- W2006350083 cites W1967633197 @default.
- W2006350083 cites W1969411648 @default.
- W2006350083 cites W1970355156 @default.
- W2006350083 cites W1971643509 @default.
- W2006350083 cites W1971923290 @default.
- W2006350083 cites W1975907310 @default.
- W2006350083 cites W1976696423 @default.
- W2006350083 cites W1977646446 @default.
- W2006350083 cites W1978337436 @default.
- W2006350083 cites W1979390437 @default.
- W2006350083 cites W1979873003 @default.
- W2006350083 cites W1980269624 @default.
- W2006350083 cites W1981259148 @default.
- W2006350083 cites W1982857973 @default.
- W2006350083 cites W1984109071 @default.
- W2006350083 cites W1985140771 @default.
- W2006350083 cites W1985974546 @default.
- W2006350083 cites W1986574361 @default.
- W2006350083 cites W1987346834 @default.
- W2006350083 cites W1989454102 @default.
- W2006350083 cites W1990636994 @default.
- W2006350083 cites W1991771106 @default.
- W2006350083 cites W1994207095 @default.
- W2006350083 cites W1994978160 @default.
- W2006350083 cites W1996804621 @default.
- W2006350083 cites W2000006880 @default.
- W2006350083 cites W2000241413 @default.
- W2006350083 cites W2003507585 @default.
- W2006350083 cites W2006765654 @default.
- W2006350083 cites W2008559030 @default.
- W2006350083 cites W2009078306 @default.
- W2006350083 cites W2009127910 @default.
- W2006350083 cites W2010438982 @default.
- W2006350083 cites W2011072606 @default.
- W2006350083 cites W2013752448 @default.
- W2006350083 cites W2014064723 @default.
- W2006350083 cites W2014946489 @default.
- W2006350083 cites W2015552915 @default.
- W2006350083 cites W2015616869 @default.
- W2006350083 cites W2017286564 @default.
- W2006350083 cites W2017444975 @default.
- W2006350083 cites W2017515700 @default.
- W2006350083 cites W2018902479 @default.
- W2006350083 cites W2020787001 @default.
- W2006350083 cites W2024316824 @default.
- W2006350083 cites W2026444780 @default.
- W2006350083 cites W2029827106 @default.
- W2006350083 cites W2030621748 @default.
- W2006350083 cites W2031374034 @default.
- W2006350083 cites W2036404063 @default.
- W2006350083 cites W2037067282 @default.
- W2006350083 cites W2041375942 @default.
- W2006350083 cites W2041764938 @default.
- W2006350083 cites W2045402423 @default.
- W2006350083 cites W2047404721 @default.
- W2006350083 cites W2048853810 @default.
- W2006350083 cites W2049340874 @default.
- W2006350083 cites W2052312685 @default.
- W2006350083 cites W2054109341 @default.
- W2006350083 cites W2054261154 @default.
- W2006350083 cites W2056892724 @default.
- W2006350083 cites W2059382687 @default.
- W2006350083 cites W2059839011 @default.
- W2006350083 cites W2062072036 @default.
- W2006350083 cites W2062346545 @default.
- W2006350083 cites W2062498561 @default.
- W2006350083 cites W2063217898 @default.
- W2006350083 cites W2064812165 @default.
- W2006350083 cites W2065135000 @default.
- W2006350083 cites W2066213138 @default.
- W2006350083 cites W2069494011 @default.
- W2006350083 cites W2069608350 @default.
- W2006350083 cites W2070693578 @default.
- W2006350083 cites W2070889557 @default.
- W2006350083 cites W2071596792 @default.
- W2006350083 cites W2073626044 @default.
- W2006350083 cites W2073718731 @default.
- W2006350083 cites W2074713417 @default.
- W2006350083 cites W2074908220 @default.
- W2006350083 cites W2076136918 @default.