Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006353558> ?p ?o ?g. }
- W2006353558 endingPage "e870" @default.
- W2006353558 startingPage "e870" @default.
- W2006353558 abstract "Filopodia, which are actin-rich finger-like membrane protrusions, have an important role in cell migration and tumor metastasis. Here we identify 13 novel calumenin (Calu) isoforms (Calu 3-15) produced by alternative splicing, and find that Calu-15 promotes filopodia formation and cell migration. Calu-15 shuttles between the nucleus and cytoplasm through interacting with importin α, Ran GTPase, and Crm1. The phosphorylation of the threonine at position 73 (Thr-73) by casein kinase 2 (CK2) is essential for the nuclear import of Calu-15, and either Thr-73 mutation or inhibition of CK2 interrupts its nuclear localization. In the nucleus, Calu-15 increases the transcription of growth differentiation factor-15 (GDF-15), a member of the transforming growth factor-β (TGF-β) superfamily, via binding to its promoter region. Furthermore, Calu-15 induces filopodia formation mediated by GDF-15. Together, we identify that Calu-15, a novel isoform of Calu with phosphorylation-dependent nuclear localization, has a critical role in promoting filopodia formation and cell migration by upregulating the GDF-15 transcription." @default.
- W2006353558 created "2016-06-24" @default.
- W2006353558 creator A5001291862 @default.
- W2006353558 creator A5013341573 @default.
- W2006353558 creator A5013951534 @default.
- W2006353558 creator A5033241557 @default.
- W2006353558 creator A5036773185 @default.
- W2006353558 creator A5048048280 @default.
- W2006353558 creator A5060887077 @default.
- W2006353558 creator A5062513274 @default.
- W2006353558 creator A5064677712 @default.
- W2006353558 creator A5079546581 @default.
- W2006353558 date "2013-10-17" @default.
- W2006353558 modified "2023-10-07" @default.
- W2006353558 title "Calumenin-15 facilitates filopodia formation by promoting TGF-β superfamily cytokine GDF-15 transcription" @default.
- W2006353558 cites W1976290313 @default.
- W2006353558 cites W1985058596 @default.
- W2006353558 cites W1991944021 @default.
- W2006353558 cites W1993148712 @default.
- W2006353558 cites W1993784521 @default.
- W2006353558 cites W2010098178 @default.
- W2006353558 cites W2012932145 @default.
- W2006353558 cites W2014350034 @default.
- W2006353558 cites W2016153572 @default.
- W2006353558 cites W2022825062 @default.
- W2006353558 cites W2023370720 @default.
- W2006353558 cites W2024750925 @default.
- W2006353558 cites W2025969523 @default.
- W2006353558 cites W2026290208 @default.
- W2006353558 cites W2026498255 @default.
- W2006353558 cites W2026974388 @default.
- W2006353558 cites W2035032425 @default.
- W2006353558 cites W2037164834 @default.
- W2006353558 cites W2038634187 @default.
- W2006353558 cites W2048492672 @default.
- W2006353558 cites W2048600907 @default.
- W2006353558 cites W2051653133 @default.
- W2006353558 cites W2053042661 @default.
- W2006353558 cites W2058699283 @default.
- W2006353558 cites W2064347847 @default.
- W2006353558 cites W2066828652 @default.
- W2006353558 cites W2069253142 @default.
- W2006353558 cites W2074239088 @default.
- W2006353558 cites W2085037886 @default.
- W2006353558 cites W2086761959 @default.
- W2006353558 cites W2107277218 @default.
- W2006353558 cites W2108442683 @default.
- W2006353558 cites W2109560931 @default.
- W2006353558 cites W2120018484 @default.
- W2006353558 cites W2120728889 @default.
- W2006353558 cites W2122194059 @default.
- W2006353558 cites W2125117217 @default.
- W2006353558 cites W2126527070 @default.
- W2006353558 cites W2138373575 @default.
- W2006353558 cites W2139043430 @default.
- W2006353558 cites W2144878837 @default.
- W2006353558 cites W2149972103 @default.
- W2006353558 cites W2150548551 @default.
- W2006353558 cites W2154840175 @default.
- W2006353558 cites W2156891333 @default.
- W2006353558 cites W2159083300 @default.
- W2006353558 cites W2164495477 @default.
- W2006353558 cites W2165911027 @default.
- W2006353558 cites W2166063947 @default.
- W2006353558 cites W2171258458 @default.
- W2006353558 cites W2314593430 @default.
- W2006353558 cites W4213141530 @default.
- W2006353558 doi "https://doi.org/10.1038/cddis.2013.403" @default.
- W2006353558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3920949" @default.
- W2006353558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24136234" @default.
- W2006353558 hasPublicationYear "2013" @default.
- W2006353558 type Work @default.
- W2006353558 sameAs 2006353558 @default.
- W2006353558 citedByCount "21" @default.
- W2006353558 countsByYear W20063535582014 @default.
- W2006353558 countsByYear W20063535582015 @default.
- W2006353558 countsByYear W20063535582016 @default.
- W2006353558 countsByYear W20063535582017 @default.
- W2006353558 countsByYear W20063535582018 @default.
- W2006353558 countsByYear W20063535582019 @default.
- W2006353558 countsByYear W20063535582020 @default.
- W2006353558 countsByYear W20063535582021 @default.
- W2006353558 countsByYear W20063535582022 @default.
- W2006353558 crossrefType "journal-article" @default.
- W2006353558 hasAuthorship W2006353558A5001291862 @default.
- W2006353558 hasAuthorship W2006353558A5013341573 @default.
- W2006353558 hasAuthorship W2006353558A5013951534 @default.
- W2006353558 hasAuthorship W2006353558A5033241557 @default.
- W2006353558 hasAuthorship W2006353558A5036773185 @default.
- W2006353558 hasAuthorship W2006353558A5048048280 @default.
- W2006353558 hasAuthorship W2006353558A5060887077 @default.
- W2006353558 hasAuthorship W2006353558A5062513274 @default.
- W2006353558 hasAuthorship W2006353558A5064677712 @default.
- W2006353558 hasAuthorship W2006353558A5079546581 @default.
- W2006353558 hasBestOaLocation W20063535581 @default.
- W2006353558 hasConcept C104317684 @default.
- W2006353558 hasConcept C125705527 @default.
- W2006353558 hasConcept C153911025 @default.