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- W2006361725 abstract "El síndrome de sinovitis, acné, pustulosis, hiperostosis, osteítis (SAPHO) incluye un grupo de manifestaciones osteoarticulares, sobre todo hiperostosis en la pared torácica anterior, y cutáneas en forma de pustulosis palmoplantar y acné grave. En el tratamiento de dicho síndrome, de etiopatogenia desconocida, se han utilizado múltiples fármacos tales como AINE y agentes antimicrobianos. También se han empleado glucocorticoides, metotrexato, sulfasalazina y bisfosfonatos intravenosos, fundamentalmente en casos resistentes. Con la aparición de los tratamientos biológicos, indicados en determinadas enfermedades reumáticas, se presenta una nueva opción terapéutica especialmente en aquellos casos sin ningún tipo de respuesta. Los fármacos anti-TNF-α, concretamente infliximab y etanercept, se han utilizado en pequeñas series y casos aislados. Los resultados obtenidos en general han sido satisfactorios, proporcionando una alternativa eficaz a los tratamientos convencionales. SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) encompasses a group of osteoarticular manifestations, especially hyperostosis in the joints and bones of the anterior chest wall and skin in the form of severe acne or hidradenitis. In the treatment of this syndrome, whose pathogenesis is unknown, many drugs have been used such as nonsteroidal anti-inflammatory agents and antibiotics. Corticosteroids, methotrexate, sulfasalazine and intravenous bisphosphonates have been used mainly in refractory cases. The development of biological treatments, indicated in certain rheumatic diseases, has provided a new therapeutic option, especially in patients without response. Anti-tumor necrosis factor-alfa agents, specifically infliximab and etanercept, have been used in isolated cases and small series. In general, the results have been satisfactory and these drugs can be an effective alternative to conventional treatments." @default.
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- W2006361725 date "2010-01-01" @default.
- W2006361725 modified "2023-09-27" @default.
- W2006361725 title "Síndrome de sinovitis, acné, pustulosis, hiperostosis, osteítis y tratamiento con antagonistas del factor de necrosis tumoral" @default.
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- W2006361725 doi "https://doi.org/10.1016/j.semreu.2009.10.001" @default.
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