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• W2006363107 abstract "298 There is a dearth of information on renal transplantation in sickle cell disease (SSD) patients with end-stage renal disease (ESRD). The last multicenter SSD Registry data was published in 1987 (Chatterjee S, Transplantation Proceedings, 1987). ESRD data on patients with SSD/trait was extracted from the USRDS 1997 Annual Data Report. From 1991-1995 there were 291 SSD/trait patients from a total of 305,876 patients on dialysis, an incidence of 0.1%. Most patients were 20-64 yr. of age (91%) and the median age was 38 yr. (median age of all ESRD patients was 63 yr.). There were 53.4% males and 46.6% females. The majority of patients were black (92.1%). Renal transplantation in the first year of dialysis was accomplished in 1.9% SSD/trait patients aged 20 - 64 yr. compared to 6.1% overall. Also, in the same age group, the mortality rate in the first year of dialysis was higher in SSD/trait patients who did not undergo renal transplantation (16.8%) compared to the general population of ESRD patients (10.2%). Renal transplantation data was obtained from the UNOS 1998 Registry. From 1988-1997, 71 SSD patients underwent renal transplantation. There were 46 males (65%) and 25 females (35%). The mean age was 33 ± 12 yr. There were 67 listed as black, 3 as white, and 1 as Hispanic. Most patients were from regions 2 (15 patients), 3 (15 patients), and 11 (10 patients) and least were from regions 6 (1 patient), 1 (2 patients) and 5 (2 patients). At 2.3 ± 2.2 yr.. (range 1 mth. - 9 yr.) of follow-up 46 patients (64.7%) were reported alive, 20 (28.1%) dead, and 5 (7.2%) missing. At one year after renal transplantation 81% (n=63 patients) had functioning grafts and 19% had graft loss from graft failure or death. At two years 67% (n=51 patients) had functioning grafts and 33% had graft loss from graft failure or death. The data are incomplete as to the number of episodes of acute rejection, recurrence of disease, reason for loss of renal transplant function, and causes of death. Conclusions: 1. SSD is an uncommon cause of ESRD. 2. Most ESRD patients with SSD are young and probably reasonable candidates for renal transplantation. 3. Fewer SSD patients received renal transplants in the first year of dialysis than in the general dialysis population. 4. The first-year mortality of SSD patients on dialysis is higher than the overall ESRD population. 5. The 1- and 2-year graft function in SSD patients is comparable to other renal diseases suggesting that renal transplantation should be considered in ESRD patients with SSD." @default.
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• W2006363107 date "1999-05-01" @default.
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• W2006363107 title "RENAL TRANSPLANTATION IN SICKLE CELL DISEASE PATIENTS WITH END-STAGE RENAL DISEASE" @default.
• W2006363107 doi "https://doi.org/10.1097/00007890-199905150-00322" @default.
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