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- W2006364047 abstract "The role of cytokines in the regulation of articular inflammation and cartilage degradation was evaluated in the rabbit model of Haemophilus influenzae type b arthritis. At 6 and 12 h after intraarticular infection, treatment with IB4 monoclonal antibody to the CD18 leukocyte receptor alone or in combination with dexamethasone resulted in significant reduction of synovial fluid (SF) neutrophil concentration. Treatment with dexamethasone alone was associated with lower SF concentrations of interleukin-1 (lL-1), tumor necrosis factor-α, and strome lysin than in other groups. At 24 h after infection, increased cartilage degradation was detected in untreated controls and in animals treated with IB4 alone or in combination with dexamethasone compared with those treated with dexamethasone alone. Multiple regression analyses indicated SF concentration of IL-1 and strome lysin as the significant predictors of cartilage degradation. These data suggest that IL-1 mediates cartilage degradation by regulation of metalloproteinases, such as stromelysin, during acute experimental bacterial arthritis." @default.
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- W2006364047 date "1993-11-01" @default.
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- W2006364047 title "Dexamethasone Attenuation of Cytokine-Mediated Articular Cartilage Degradation in Experimental Lapine Haemophilus Arthritis" @default.
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- W2006364047 doi "https://doi.org/10.1093/infdis/168.5.1186" @default.
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