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- W2006365364 abstract "Intestinal ischemia/reperfusion (IR) injury often sets the stage for subsequent development of gut necrosis. Pentoxifylline (PTX) is known to be to increase RBC deformability and prostacyclin release, both improving the microcirculation; to decrease the adhesiveness of activated PMN's, potentially reducing subsequent release of autodestructive myeloperoxidase and superoxide radicals, and to inhibit production of cytokine mediators. We hypothesized, therefore, that PTX would be effective in ameliorating intestinal necrosis resulting from IR injury. Methods Adult rats were anesthetized with pentobarbital; their abdomens surgically opened and intestinal vasculature exposed; and assigned to one of three groups: Control(n=7)- no further intervention; IR (n=9)- after stabilization, the superior and inferior mesenteric arteries were clamped for 45 minutes, and then perfusion was re-established; PTX (n=9)- same as IR protocol, but animals were treated with PTX at baseline (BL), 30 and 60 min. Blood was taken for measurement of Thiobarbituric Acid Reducing Substances (TBARS), a measure of lipid peroxidation, at BL, 45 min. (end of ischemia for latter groups), and at 60 and 75 min (15 and 30 min. of reperfusion for latter groups). At the conclusion of the experiment, intestinal samples were removed and preserved in formalin for histological examination. Pathologic lesions were graded from 0(no lesions) to 3(severe lesions) Results TBARS of the three groups are presented graphically (IR vs. both other groups; p<0.05). Pathological scores were 0±0, 2.92±0.20 and 1.17±0.52 for the control, ischemia and PTX groups respectively(p=0.0005). Conclusion IR injury was associated with increased lipid peroxidation and necrotic lesions in the rat intestine. PTX ameliorated both of these processes. Figure" @default.
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- W2006365364 date "1996-04-01" @default.
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- W2006365364 title "Pentoxifylline Ameliorates Ischemia/Reperfusion Injury in Rat Intestine• 702" @default.
- W2006365364 doi "https://doi.org/10.1203/00006450-199604001-00724" @default.
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