Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006367248> ?p ?o ?g. }
- W2006367248 endingPage "61" @default.
- W2006367248 startingPage "55" @default.
- W2006367248 abstract "Neuropeptide Y (NPY), which is synthesized in neurons of the arcuate nucleus (ARC) that project to different hypothalamic nuclei, is known to have potent effects on eating behavior and hormone secretion after hypothalamic administration. To test the hypothesis that endogenous NPY is essential for the normal expression of these responses, the present study used to unmodified antisense oligodeoxynucleotides (ODNs) to disrupt the synthesis of NPY in the ARC and to examine the impact of this disturbance on nutrient intake, as well as on circulating levels of insulin and the adrenal steroids, corticosterone and aldosterone. Brain-cannulated rats maintained on macronutrient diets were given daily, bilateral injections, over a 4-day period, of NPY antisense ODNs, sense ODNs or saline into the ARC. The NPY antisense ODNs produced a significant decline (-33% relative to sense ODNs and -40% relative to saline, P < 0.05) in NPY levels in this nucleus, without causing any direct neural damage. Peptide levels in other hypothalamic areas, namely, the paraventricular nucleus and medial preoptic nucleus, were not significantly affected. In association with this reduction in ARC NPY, the antisense-treated animals exhibited a significant decrease in feeding behavior measured during the first 90 min of the natural feeding cycle, as well as over the 24-h period. In the 90-min interval, both carbohydrate and fat intake were suppressed by 65-70% (P < 0.05, relative to both saline and sense ODNs control scores).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2006367248 created "2016-06-24" @default.
- W2006367248 creator A5001217186 @default.
- W2006367248 creator A5045559088 @default.
- W2006367248 creator A5063089135 @default.
- W2006367248 creator A5090507281 @default.
- W2006367248 date "1994-01-01" @default.
- W2006367248 modified "2023-10-03" @default.
- W2006367248 title "Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion" @default.
- W2006367248 cites W1775749144 @default.
- W2006367248 cites W1964672426 @default.
- W2006367248 cites W1966464425 @default.
- W2006367248 cites W1986209395 @default.
- W2006367248 cites W1987289944 @default.
- W2006367248 cites W1988975012 @default.
- W2006367248 cites W1989719288 @default.
- W2006367248 cites W1991123973 @default.
- W2006367248 cites W1992254318 @default.
- W2006367248 cites W1993990935 @default.
- W2006367248 cites W1995958310 @default.
- W2006367248 cites W2017763577 @default.
- W2006367248 cites W2024509963 @default.
- W2006367248 cites W2026157681 @default.
- W2006367248 cites W2030366306 @default.
- W2006367248 cites W2031092694 @default.
- W2006367248 cites W2031463222 @default.
- W2006367248 cites W2039225920 @default.
- W2006367248 cites W2042288907 @default.
- W2006367248 cites W2053448608 @default.
- W2006367248 cites W2053807193 @default.
- W2006367248 cites W2054036668 @default.
- W2006367248 cites W2055978224 @default.
- W2006367248 cites W2063690714 @default.
- W2006367248 cites W2067193940 @default.
- W2006367248 cites W2075390326 @default.
- W2006367248 cites W2078073869 @default.
- W2006367248 cites W2079803201 @default.
- W2006367248 cites W2082706052 @default.
- W2006367248 cites W2085136188 @default.
- W2006367248 cites W2086496276 @default.
- W2006367248 cites W2092151279 @default.
- W2006367248 cites W2097378006 @default.
- W2006367248 cites W2162355702 @default.
- W2006367248 cites W2163143518 @default.
- W2006367248 cites W2163883645 @default.
- W2006367248 cites W4249690187 @default.
- W2006367248 cites W4256704856 @default.
- W2006367248 doi "https://doi.org/10.1016/0169-328x(94)90377-8" @default.
- W2006367248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8164522" @default.
- W2006367248 hasPublicationYear "1994" @default.
- W2006367248 type Work @default.
- W2006367248 sameAs 2006367248 @default.
- W2006367248 citedByCount "171" @default.
- W2006367248 countsByYear W20063672482018 @default.
- W2006367248 countsByYear W20063672482019 @default.
- W2006367248 countsByYear W20063672482020 @default.
- W2006367248 crossrefType "journal-article" @default.
- W2006367248 hasAuthorship W2006367248A5001217186 @default.
- W2006367248 hasAuthorship W2006367248A5045559088 @default.
- W2006367248 hasAuthorship W2006367248A5063089135 @default.
- W2006367248 hasAuthorship W2006367248A5090507281 @default.
- W2006367248 hasConcept C118303440 @default.
- W2006367248 hasConcept C126322002 @default.
- W2006367248 hasConcept C134018914 @default.
- W2006367248 hasConcept C16613235 @default.
- W2006367248 hasConcept C170493617 @default.
- W2006367248 hasConcept C2524010 @default.
- W2006367248 hasConcept C2777003273 @default.
- W2006367248 hasConcept C2778458369 @default.
- W2006367248 hasConcept C2780352252 @default.
- W2006367248 hasConcept C33923547 @default.
- W2006367248 hasConcept C71315377 @default.
- W2006367248 hasConcept C71924100 @default.
- W2006367248 hasConcept C83415579 @default.
- W2006367248 hasConcept C86803240 @default.
- W2006367248 hasConcept C93984277 @default.
- W2006367248 hasConceptScore W2006367248C118303440 @default.
- W2006367248 hasConceptScore W2006367248C126322002 @default.
- W2006367248 hasConceptScore W2006367248C134018914 @default.
- W2006367248 hasConceptScore W2006367248C16613235 @default.
- W2006367248 hasConceptScore W2006367248C170493617 @default.
- W2006367248 hasConceptScore W2006367248C2524010 @default.
- W2006367248 hasConceptScore W2006367248C2777003273 @default.
- W2006367248 hasConceptScore W2006367248C2778458369 @default.
- W2006367248 hasConceptScore W2006367248C2780352252 @default.
- W2006367248 hasConceptScore W2006367248C33923547 @default.
- W2006367248 hasConceptScore W2006367248C71315377 @default.
- W2006367248 hasConceptScore W2006367248C71924100 @default.
- W2006367248 hasConceptScore W2006367248C83415579 @default.
- W2006367248 hasConceptScore W2006367248C86803240 @default.
- W2006367248 hasConceptScore W2006367248C93984277 @default.
- W2006367248 hasIssue "1-2" @default.
- W2006367248 hasLocation W20063672481 @default.
- W2006367248 hasLocation W20063672482 @default.
- W2006367248 hasOpenAccess W2006367248 @default.
- W2006367248 hasPrimaryLocation W20063672481 @default.
- W2006367248 hasRelatedWork W1965857465 @default.
- W2006367248 hasRelatedWork W2057629453 @default.