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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006372009> ?p ?o ?g. }

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• W2006372009 abstract "The synthetic lipopeptide Pam3Cys-Ser-Ser-Asn-Ala, an analogue of the N-terminal part of bacterial lipoprotein, constitutes a potent macrophage and B lymphocyte activator. In the macrophage cell-line P388D1 Pam3Cys-Ser-Ser-Asn-Ala stimulated phosphoinositol turnover, whereas in small resting lymphocytes no enhanced turnover was observed. Upon lipopeptide stimulation, a translocation of PKC from the cytosol to the plasma membrane was found in the cell line P388D1 but not in lymphocytes. Substituting lipopeptide for diacylglycerol shows that Pam3Cys-Ser-Ser-Asn-Ala leads to an activation of protein kinase C at Ca2+ concentrations of 0.5 mM. Thus, mitogenic lipopeptides constitute novel tools for investigating the molecular mechanism of transmembrane signaling in leukocyte activation." @default.
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• W2006372009 date "1988-07-01" @default.
• W2006372009 modified "2023-09-27" @default.
• W2006372009 title "Phosphatidylinositol Metabolism and Protein Kinase C Activation in Leukocytes by Lipopeptides" @default.
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• W2006372009 doi "https://doi.org/10.1016/s0171-2985(88)80046-9" @default.
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