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- W2006372716 abstract "B-cell lymphomas express tumor-specific immunoglobulin, the variable regions of which (Id determinants) are tumor-specific antigens and therefore are suitable targets for vaccine immunotherapy. Promising results have been obtained in clinical studies of Id vaccination using Id proteins or naked DNA Id vaccines. Several reports have indicated that the immunodominant epitopes of the clone-specific Ig lie within the hypervariable CDR3 regions. Our group has previously tested the possibility of using the short peptide encompassing the CDR3 of immunoglobulin heavy chain (VH-CDR3) as a target for eliciting a tumor specific immune response via DNA-based vaccination. We demonstrated that DNA immunization of outbred mice with different patient-derived VH-CDR3 peptides elicited antibodies able to recognize native antigens on individual patient's tumor cells. These findings prompted us to investigate the immune response and tumor protection following CDR3-based DNA vaccination in the 38C13 B lymphoma as tumor model." @default.
- W2006372716 created "2016-06-24" @default.
- W2006372716 date "2005-05-01" @default.
- W2006372716 modified "2023-09-25" @default.
- W2006372716 title "706. DNA Vaccine Strategy Against Chronic B-Cell Lymphoma: Anti-Idiotypic CDR3 Vaccination" @default.
- W2006372716 doi "https://doi.org/10.1016/j.ymthe.2005.07.246" @default.
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