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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006375023> ?p ?o ?g. }

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• W2006375023 abstract "A novel series of pyridazinone analogs has been developed as potent β-1,3-glucan synthase inhibitors through structure–activity relationship study of the lead 5-[4-(benzylsulfonyl)piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one (1). The effect of changes to the core structure is described in detail. Optimization of the sulfonamide moiety led to the identification of important compounds with much improved systematic exposure while retaining good antifungal activity against the fungal strains Candida glabrata and Candida albicans." @default.
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• W2006375023 date "2011-05-01" @default.
• W2006375023 modified "2023-10-18" @default.
• W2006375023 title "SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors" @default.
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• W2006375023 doi "https://doi.org/10.1016/j.bmcl.2011.03.083" @default.
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