Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006375585> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2006375585 endingPage "635" @default.
- W2006375585 startingPage "631" @default.
- W2006375585 abstract "Starch microspheres 40 μm in diameter, which are rapidly degraded by serum amylase, have been administered through hepatic arterial catheters to five patients with primary and metastatic liver cancer to determine whether (1) arterial blood flow through the liver could be temporarily blocked, and (2) such occlusion at the level of the arteriolar capillary bed would enhance regional uptake and catabolism and decrease systemic exposure to simultaneously administered hepatic arterial bischlorethylnitrosourea (BCNU). It was possible with 10 ml of microspheres (9 × 106 microspheres/ml) injected into the hepatic artery to transiently (for 15-30 minutes) reduce hepatic flow by 80-100% in the five patients. When BCNU (50 mg/m2 in one minute) was given with microspheres there was a 30-90% reduction in systemic nitrosourea exposure and in peak levels. No myelosuppression was noted and hepatic toxicity consisted of acute pain due to BCNU and 1.5-2.0 fold transient enzyme elevations. One patient with cholangiocarcinoma showed a partial response lasting three months; three patients had stable disease and one patient with colon carcinoma had progressive disease. Thus, this pilot study suggests that concurrent intra-arterial microspheres and BCNU may have the potential to improve selective regional drug effect with marked diminution in systemic toxicity." @default.
- W2006375585 created "2016-06-24" @default.
- W2006375585 creator A5003555402 @default.
- W2006375585 creator A5020818775 @default.
- W2006375585 creator A5064449830 @default.
- W2006375585 creator A5067078236 @default.
- W2006375585 creator A5073269496 @default.
- W2006375585 creator A5082914796 @default.
- W2006375585 date "1982-08-15" @default.
- W2006375585 modified "2023-10-16" @default.
- W2006375585 title "Improved regional selectivity of hepatic arterial bcnu with degradable microspheres" @default.
- W2006375585 cites W1982424018 @default.
- W2006375585 cites W2005887005 @default.
- W2006375585 cites W2034432269 @default.
- W2006375585 cites W2040715219 @default.
- W2006375585 cites W2049900561 @default.
- W2006375585 cites W2060817769 @default.
- W2006375585 cites W2157828239 @default.
- W2006375585 cites W2409186476 @default.
- W2006375585 cites W4234095394 @default.
- W2006375585 doi "https://doi.org/10.1002/1097-0142(19820815)50:4<631::aid-cncr2820500403>3.0.co;2-m" @default.
- W2006375585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7046907" @default.
- W2006375585 hasPublicationYear "1982" @default.
- W2006375585 type Work @default.
- W2006375585 sameAs 2006375585 @default.
- W2006375585 citedByCount "137" @default.
- W2006375585 countsByYear W20063755852012 @default.
- W2006375585 countsByYear W20063755852013 @default.
- W2006375585 countsByYear W20063755852014 @default.
- W2006375585 countsByYear W20063755852018 @default.
- W2006375585 countsByYear W20063755852019 @default.
- W2006375585 countsByYear W20063755852020 @default.
- W2006375585 countsByYear W20063755852023 @default.
- W2006375585 crossrefType "journal-article" @default.
- W2006375585 hasAuthorship W2006375585A5003555402 @default.
- W2006375585 hasAuthorship W2006375585A5020818775 @default.
- W2006375585 hasAuthorship W2006375585A5064449830 @default.
- W2006375585 hasAuthorship W2006375585A5067078236 @default.
- W2006375585 hasAuthorship W2006375585A5073269496 @default.
- W2006375585 hasAuthorship W2006375585A5082914796 @default.
- W2006375585 hasConcept C121608353 @default.
- W2006375585 hasConcept C126322002 @default.
- W2006375585 hasConcept C127413603 @default.
- W2006375585 hasConcept C158846371 @default.
- W2006375585 hasConcept C189942447 @default.
- W2006375585 hasConcept C2778405590 @default.
- W2006375585 hasConcept C29730261 @default.
- W2006375585 hasConcept C42360764 @default.
- W2006375585 hasConcept C526805850 @default.
- W2006375585 hasConcept C71924100 @default.
- W2006375585 hasConcept C90924648 @default.
- W2006375585 hasConcept C98274493 @default.
- W2006375585 hasConceptScore W2006375585C121608353 @default.
- W2006375585 hasConceptScore W2006375585C126322002 @default.
- W2006375585 hasConceptScore W2006375585C127413603 @default.
- W2006375585 hasConceptScore W2006375585C158846371 @default.
- W2006375585 hasConceptScore W2006375585C189942447 @default.
- W2006375585 hasConceptScore W2006375585C2778405590 @default.
- W2006375585 hasConceptScore W2006375585C29730261 @default.
- W2006375585 hasConceptScore W2006375585C42360764 @default.
- W2006375585 hasConceptScore W2006375585C526805850 @default.
- W2006375585 hasConceptScore W2006375585C71924100 @default.
- W2006375585 hasConceptScore W2006375585C90924648 @default.
- W2006375585 hasConceptScore W2006375585C98274493 @default.
- W2006375585 hasIssue "4" @default.
- W2006375585 hasLocation W20063755851 @default.
- W2006375585 hasLocation W20063755852 @default.
- W2006375585 hasOpenAccess W2006375585 @default.
- W2006375585 hasPrimaryLocation W20063755851 @default.
- W2006375585 hasRelatedWork W1967955749 @default.
- W2006375585 hasRelatedWork W2011061267 @default.
- W2006375585 hasRelatedWork W2043172820 @default.
- W2006375585 hasRelatedWork W2112727823 @default.
- W2006375585 hasRelatedWork W2225808413 @default.
- W2006375585 hasRelatedWork W2320501088 @default.
- W2006375585 hasRelatedWork W2397482356 @default.
- W2006375585 hasRelatedWork W2414453160 @default.
- W2006375585 hasRelatedWork W3204839132 @default.
- W2006375585 hasRelatedWork W4386237970 @default.
- W2006375585 hasVolume "50" @default.
- W2006375585 isParatext "false" @default.
- W2006375585 isRetracted "false" @default.
- W2006375585 magId "2006375585" @default.
- W2006375585 workType "article" @default.