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- W2006376170 abstract "Summary The gonadal regulation of synthesis and catabolism of cholesterol in the liver and its relationship with serum cholesterol level have been investigated in intact, gonadectomized and hormone-treated rats in the presence and absence of dietary fat as well as cholesterol. Although, females have higher rates for synthesis and breakdown of cholesterol in the liver than males, they exhibit higher serum cholesterol values. Gonadectomy reduces biogenesis of cholesterol in the liver, while rates of catabolism are increased in males and decreased in females following hormone depletion and these effects are reversed by hormone replacement. Exclusion of fat from the diet caused marked lowering of rates of synthesis but is without any influence on sterol degradation in the liver. On a cholesterol diet, however, catabolism is stimulated, but synthesis reduced. Hormonal influences on catabolism were more enhanced in cholesterol-fed animals, but their effects on synthesis in animals on a cholesterol or fat-free diet were not clear-cut due to very low rates of conversion of acetate to cholesterol in the liver. A positive correlation between serum cholesterol and hepatic rates of synthesis and breakdown in various endocrine states has not been obtained, probably due to the influences of hormone administration or withdrawal on other endocrine systems which usually function in an integrated manner." @default.
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- W2006376170 title "Effects of gonadal hormones on cholesterol metabolism in the rat" @default.
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