Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006378039> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2006378039 endingPage "e0117580" @default.
- W2006378039 startingPage "e0117580" @default.
- W2006378039 abstract "The development of new therapeutic strategies for the treatment of complex brain disorders such as drug addiction is likely to be advanced by a more complete understanding of the underlying molecular pathophysiology. Although the study of postmortem human brain represents a unique resource in this regard, it can be challenging to disentangle the relative contribution of chronic pathological processes versus perimortem events to the observed changes in gene expression. To begin to unravel this issue, we analyzed by quantitative PCR the midbrain expression of numerous candidate genes previously associated with cocaine abuse. Data obtained from chronic cocaine abusers (and matched control subjects) dying of gunshot wounds were compared with a prior study of subjects with deaths directly attributable to cocaine abuse. Most of the genes studied (i.e., tyrosine hydroxylase, dopamine transporter, forkhead box A2, histone variant H3 family 3B, nuclear factor kappa B inhibitor alpha, growth arrest and DNA damage-inducible beta) were found to be differentially expressed in chronic cocaine abusers irrespective of immediate cause of death or perimortem levels of cocaine, suggesting that these may represent core pathophysiological changes arising with chronic drug abuse. On the other hand, chemokine C-C motif ligand 2 and jun proto-oncogene expression were unaffected in cocaine-abusing subjects dying of gunshot wounds, in contrast to the differential expression previously reported in cocaine-related fatalities. The possible influence of cause of death and other factors on the cocaine-responsiveness of these genes is discussed." @default.
- W2006378039 created "2016-06-24" @default.
- W2006378039 creator A5004246605 @default.
- W2006378039 creator A5004739225 @default.
- W2006378039 creator A5029209818 @default.
- W2006378039 creator A5045236251 @default.
- W2006378039 creator A5085846904 @default.
- W2006378039 date "2015-02-06" @default.
- W2006378039 modified "2023-10-14" @default.
- W2006378039 title "Investigating the Potential Influence of Cause of Death and Cocaine Levels on the Differential Expression of Genes Associated with Cocaine Abuse" @default.
- W2006378039 cites W1553398873 @default.
- W2006378039 cites W1669099788 @default.
- W2006378039 cites W1696199194 @default.
- W2006378039 cites W1966207206 @default.
- W2006378039 cites W1979456591 @default.
- W2006378039 cites W2016079510 @default.
- W2006378039 cites W2016441739 @default.
- W2006378039 cites W2020065445 @default.
- W2006378039 cites W2032503223 @default.
- W2006378039 cites W2043269926 @default.
- W2006378039 cites W2066848874 @default.
- W2006378039 cites W2067147530 @default.
- W2006378039 cites W2094750093 @default.
- W2006378039 cites W2131543691 @default.
- W2006378039 cites W2140600148 @default.
- W2006378039 cites W2148195276 @default.
- W2006378039 cites W2153122353 @default.
- W2006378039 cites W2166284137 @default.
- W2006378039 cites W2514160263 @default.
- W2006378039 cites W4248171647 @default.
- W2006378039 doi "https://doi.org/10.1371/journal.pone.0117580" @default.
- W2006378039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4319936" @default.
- W2006378039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25658879" @default.
- W2006378039 hasPublicationYear "2015" @default.
- W2006378039 type Work @default.
- W2006378039 sameAs 2006378039 @default.
- W2006378039 citedByCount "12" @default.
- W2006378039 countsByYear W20063780392015 @default.
- W2006378039 countsByYear W20063780392016 @default.
- W2006378039 countsByYear W20063780392017 @default.
- W2006378039 countsByYear W20063780392018 @default.
- W2006378039 countsByYear W20063780392019 @default.
- W2006378039 countsByYear W20063780392020 @default.
- W2006378039 countsByYear W20063780392022 @default.
- W2006378039 countsByYear W20063780392023 @default.
- W2006378039 crossrefType "journal-article" @default.
- W2006378039 hasAuthorship W2006378039A5004246605 @default.
- W2006378039 hasAuthorship W2006378039A5004739225 @default.
- W2006378039 hasAuthorship W2006378039A5029209818 @default.
- W2006378039 hasAuthorship W2006378039A5045236251 @default.
- W2006378039 hasAuthorship W2006378039A5085846904 @default.
- W2006378039 hasBestOaLocation W20063780391 @default.
- W2006378039 hasConcept C118552586 @default.
- W2006378039 hasConcept C2779796075 @default.
- W2006378039 hasConcept C2910455596 @default.
- W2006378039 hasConcept C48856860 @default.
- W2006378039 hasConcept C71924100 @default.
- W2006378039 hasConceptScore W2006378039C118552586 @default.
- W2006378039 hasConceptScore W2006378039C2779796075 @default.
- W2006378039 hasConceptScore W2006378039C2910455596 @default.
- W2006378039 hasConceptScore W2006378039C48856860 @default.
- W2006378039 hasConceptScore W2006378039C71924100 @default.
- W2006378039 hasIssue "2" @default.
- W2006378039 hasLocation W20063780391 @default.
- W2006378039 hasLocation W20063780392 @default.
- W2006378039 hasLocation W20063780393 @default.
- W2006378039 hasLocation W20063780394 @default.
- W2006378039 hasOpenAccess W2006378039 @default.
- W2006378039 hasPrimaryLocation W20063780391 @default.
- W2006378039 hasRelatedWork W15374435 @default.
- W2006378039 hasRelatedWork W1970238016 @default.
- W2006378039 hasRelatedWork W2024502785 @default.
- W2006378039 hasRelatedWork W2405353726 @default.
- W2006378039 hasRelatedWork W2408759955 @default.
- W2006378039 hasRelatedWork W2416723105 @default.
- W2006378039 hasRelatedWork W2419192334 @default.
- W2006378039 hasRelatedWork W2618299345 @default.
- W2006378039 hasRelatedWork W4247649320 @default.
- W2006378039 hasRelatedWork W892200030 @default.
- W2006378039 hasVolume "10" @default.
- W2006378039 isParatext "false" @default.
- W2006378039 isRetracted "false" @default.
- W2006378039 magId "2006378039" @default.
- W2006378039 workType "article" @default.