FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006388599> ?p ?o ?g. }

• W2006388599 endingPage "31" @default.
• W2006388599 startingPage "11" @default.
• W2006388599 abstract "Analysis of 100K-defective temperature-sensitive adenovirus mutants confirmed the multifunctional character of the nonstructural, virus-coded 100K protein. In addition to its function in hexon trimerization (altered in H5ts1), and its possible direct or indirect role in hexon transport to nucleus (mutated in H2ts118), genetic and biochemical evidence was presented that 100K play some critical role in the scaffolding process of adenovirus capsid. This function appeared to be defective in H2t8107 and to map between coordinates 69.0 and 69.9, leftward from the H5ts1 lesion (70–73 map units; Arrand, 1978). This corresponded to the central domain of the 100K protein, between amino acid 300 and 400 from the N end. DNA sequencing of cloned fragments of H2ts107 DNA overlapping the mutation revealed two point mutations on the same codon at nucleotide 25,082 and 25,083 (GAC → GCA), corresponding to a nonconservative amino acid change (aspartic acid → alanine) at position 324 in the 100K sequence. 100K of adenovirus 2 wild type (WT) was found to bind in significant amounts to novobiocin-affinity column, and to be coeluted with hexon, penton, IIIa, and cellular topoisomerase II activity, by novobiocin- or ATP-Mg2+-containing buffers. H2ts107100K also bound to novobiocin column, but the elution pattern differed from that of WT, suggesting some alteration in the affinity of the mutated 100K for novobiocin. The same behavior on affinity column as H2ts107 100K was observed for 90K, a cleavage product of the 100K, found in great abundance in H2ts107 at 39.5° and corresponding to the C-terminal moiety of the 100K molecule. This implied that the “novobiocin-binding” domain of the 100K was not confined at its N terminus, and was altered in the H2ts107 mutant." @default.
• W2006388599 created "2016-06-24" @default.
• W2006388599 creator A5025876236 @default.
• W2006388599 creator A5077966534 @default.
• W2006388599 date "1986-07-01" @default.
• W2006388599 modified "2023-09-29" @default.
• W2006388599 title "Hexon trimerization occurring in an assembly-defective, 100k temperature-sensitive mutant of adenovirus 2" @default.
• W2006388599 cites W1417875345 @default.
• W2006388599 cites W1482837543 @default.
• W2006388599 cites W1483224871 @default.
• W2006388599 cites W1491962466 @default.
• W2006388599 cites W1504558880 @default.
• W2006388599 cites W1526634010 @default.
• W2006388599 cites W1554252634 @default.
• W2006388599 cites W1572261142 @default.
• W2006388599 cites W1575348934 @default.
• W2006388599 cites W1601594832 @default.
• W2006388599 cites W1603502391 @default.
• W2006388599 cites W1911211105 @default.
• W2006388599 cites W1963838671 @default.
• W2006388599 cites W1975304761 @default.
• W2006388599 cites W1979321980 @default.
• W2006388599 cites W1987130177 @default.
• W2006388599 cites W1987799223 @default.
• W2006388599 cites W1988690370 @default.
• W2006388599 cites W2000687515 @default.
• W2006388599 cites W2000939182 @default.
• W2006388599 cites W2003171435 @default.
• W2006388599 cites W2003686155 @default.
• W2006388599 cites W2004885681 @default.
• W2006388599 cites W2018551927 @default.
• W2006388599 cites W2032792187 @default.
• W2006388599 cites W2040222389 @default.
• W2006388599 cites W2041938816 @default.
• W2006388599 cites W2049379969 @default.
• W2006388599 cites W2049732269 @default.
• W2006388599 cites W2050389822 @default.
• W2006388599 cites W2051717608 @default.
• W2006388599 cites W2061657917 @default.
• W2006388599 cites W2063729953 @default.
• W2006388599 cites W2067616866 @default.
• W2006388599 cites W2071325088 @default.
• W2006388599 cites W2084855813 @default.
• W2006388599 cites W2093160430 @default.
• W2006388599 cites W2100837269 @default.
• W2006388599 cites W2104266857 @default.
• W2006388599 cites W2110868147 @default.
• W2006388599 cites W2119372955 @default.
• W2006388599 cites W2126719129 @default.
• W2006388599 cites W2142365238 @default.
• W2006388599 cites W2164358316 @default.
• W2006388599 cites W2170643808 @default.
• W2006388599 cites W97692943 @default.
• W2006388599 doi "https://doi.org/10.1016/0042-6822(86)90367-3" @default.
• W2006388599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3521069" @default.
• W2006388599 hasPublicationYear "1986" @default.
• W2006388599 type Work @default.
• W2006388599 sameAs 2006388599 @default.
• W2006388599 citedByCount "34" @default.
• W2006388599 countsByYear W20063885992012 @default.
• W2006388599 countsByYear W20063885992013 @default.
• W2006388599 countsByYear W20063885992014 @default.
• W2006388599 countsByYear W20063885992016 @default.
• W2006388599 countsByYear W20063885992017 @default.
• W2006388599 countsByYear W20063885992019 @default.
• W2006388599 countsByYear W20063885992023 @default.
• W2006388599 crossrefType "journal-article" @default.
• W2006388599 hasAuthorship W2006388599A5025876236 @default.
• W2006388599 hasAuthorship W2006388599A5077966534 @default.
• W2006388599 hasConcept C104317684 @default.
• W2006388599 hasConcept C143065580 @default.
• W2006388599 hasConcept C153911025 @default.
• W2006388599 hasConcept C167625842 @default.
• W2006388599 hasConcept C176944494 @default.
• W2006388599 hasConcept C202878990 @default.
• W2006388599 hasConcept C207583985 @default.
• W2006388599 hasConcept C2776954459 @default.
• W2006388599 hasConcept C2777046247 @default.
• W2006388599 hasConcept C2779856020 @default.
• W2006388599 hasConcept C2779904463 @default.
• W2006388599 hasConcept C40767141 @default.
• W2006388599 hasConcept C501593827 @default.
• W2006388599 hasConcept C501734568 @default.
• W2006388599 hasConcept C515207424 @default.
• W2006388599 hasConcept C552990157 @default.
• W2006388599 hasConcept C55493867 @default.
• W2006388599 hasConcept C86803240 @default.
• W2006388599 hasConceptScore W2006388599C104317684 @default.
• W2006388599 hasConceptScore W2006388599C143065580 @default.
• W2006388599 hasConceptScore W2006388599C153911025 @default.
• W2006388599 hasConceptScore W2006388599C167625842 @default.
• W2006388599 hasConceptScore W2006388599C176944494 @default.
• W2006388599 hasConceptScore W2006388599C202878990 @default.
• W2006388599 hasConceptScore W2006388599C207583985 @default.
• W2006388599 hasConceptScore W2006388599C2776954459 @default.
• W2006388599 hasConceptScore W2006388599C2777046247 @default.
• W2006388599 hasConceptScore W2006388599C2779856020 @default.
• W2006388599 hasConceptScore W2006388599C2779904463 @default.

• next