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- W2006388911 abstract "4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD), we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process." @default.
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- W2006388911 date "1997-09-01" @default.
- W2006388911 modified "2023-10-16" @default.
- W2006388911 title "Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease" @default.
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- W2006388911 doi "https://doi.org/10.1016/s0197-4580(97)00108-5" @default.
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