Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006393800> ?p ?o ?g. }
- W2006393800 endingPage "946" @default.
- W2006393800 startingPage "935" @default.
- W2006393800 abstract "We have recently shown that stable expression of an epitope-tagged cDNA of the hepatocyte- enriched transcription factor, hepatocyte nuclear factor (HNF)4, in dedifferentiated rat hepatoma H5 cells is sufficient to provoke reexpression of a set of hepatocyte marker genes. Here, we demonstrate that the effects of HNF4 expression extend to the reestablishment of differentiated epithelial cell morphology and simple epithelial polarity. The acquisition of epithelial morphology occurs in two steps. First, expression of HNF4 results in reexpression of cytokeratin proteins and partial reestablishment of E-cadherin production. Only the transfectants are competent to respond to the synthetic glucocorticoid dexamethasone, which induces the second step of morphogenesis, including formation of the junctional complex and expression of a polarized cell phenotype. Cell fusion experiments revealed that the transfectant cells, which show only partial restoration of E-cadherin expression, produce an extinguisher that is capable of acting in trans to downregulate the E-cadherin gene of well-differentiated hepatoma cells. Bypass of this repression by stable expression of E-cadherin in H5 cells is sufficient to establish some epithelial cell characteristics, implying that the morphogenic potential of HNF4 in hepatic cells acts via activation of the E-cadherin gene. Thus, HNF4 seems to integrate the genetic programs of liver-specific gene expression and epithelial morphogenesis." @default.
- W2006393800 created "2016-06-24" @default.
- W2006393800 creator A5054398267 @default.
- W2006393800 creator A5064492946 @default.
- W2006393800 date "1998-02-23" @default.
- W2006393800 modified "2023-10-10" @default.
- W2006393800 title "Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells" @default.
- W2006393800 cites W1040412630 @default.
- W2006393800 cites W14570383 @default.
- W2006393800 cites W1457782476 @default.
- W2006393800 cites W1521871611 @default.
- W2006393800 cites W153332747 @default.
- W2006393800 cites W1757054819 @default.
- W2006393800 cites W1793177151 @default.
- W2006393800 cites W1807724819 @default.
- W2006393800 cites W1864480592 @default.
- W2006393800 cites W1964526847 @default.
- W2006393800 cites W1969887412 @default.
- W2006393800 cites W1971278346 @default.
- W2006393800 cites W1978016227 @default.
- W2006393800 cites W1980955976 @default.
- W2006393800 cites W1981305491 @default.
- W2006393800 cites W1989215255 @default.
- W2006393800 cites W1990283480 @default.
- W2006393800 cites W1995862211 @default.
- W2006393800 cites W2002643428 @default.
- W2006393800 cites W2005381250 @default.
- W2006393800 cites W2008714893 @default.
- W2006393800 cites W2010643478 @default.
- W2006393800 cites W2016693266 @default.
- W2006393800 cites W2018289835 @default.
- W2006393800 cites W2018371100 @default.
- W2006393800 cites W2026533505 @default.
- W2006393800 cites W2036553614 @default.
- W2006393800 cites W2037481900 @default.
- W2006393800 cites W2038305047 @default.
- W2006393800 cites W2039307052 @default.
- W2006393800 cites W2044601123 @default.
- W2006393800 cites W2045508596 @default.
- W2006393800 cites W2050750704 @default.
- W2006393800 cites W2052497886 @default.
- W2006393800 cites W2054722766 @default.
- W2006393800 cites W2055824128 @default.
- W2006393800 cites W2061385217 @default.
- W2006393800 cites W2062198383 @default.
- W2006393800 cites W2062423659 @default.
- W2006393800 cites W2070015158 @default.
- W2006393800 cites W2071802543 @default.
- W2006393800 cites W2073808856 @default.
- W2006393800 cites W2079940013 @default.
- W2006393800 cites W2080132636 @default.
- W2006393800 cites W2080694884 @default.
- W2006393800 cites W2081492347 @default.
- W2006393800 cites W2082221845 @default.
- W2006393800 cites W2084457841 @default.
- W2006393800 cites W2094091694 @default.
- W2006393800 cites W2099451303 @default.
- W2006393800 cites W2100837269 @default.
- W2006393800 cites W2102129370 @default.
- W2006393800 cites W2106104738 @default.
- W2006393800 cites W2109033138 @default.
- W2006393800 cites W2111399322 @default.
- W2006393800 cites W2113189847 @default.
- W2006393800 cites W2116615268 @default.
- W2006393800 cites W2123411193 @default.
- W2006393800 cites W2125878895 @default.
- W2006393800 cites W2129990828 @default.
- W2006393800 cites W2134812217 @default.
- W2006393800 cites W2137261534 @default.
- W2006393800 cites W2139731427 @default.
- W2006393800 cites W2143646667 @default.
- W2006393800 cites W2144300167 @default.
- W2006393800 cites W2155249371 @default.
- W2006393800 cites W2164592284 @default.
- W2006393800 cites W2166694150 @default.
- W2006393800 cites W2228395554 @default.
- W2006393800 cites W2228905202 @default.
- W2006393800 cites W2396187104 @default.
- W2006393800 cites W2407956519 @default.
- W2006393800 cites W2418393334 @default.
- W2006393800 cites W2473055700 @default.
- W2006393800 cites W287412083 @default.
- W2006393800 cites W295339133 @default.
- W2006393800 cites W4254352129 @default.
- W2006393800 cites W4294216491 @default.
- W2006393800 doi "https://doi.org/10.1083/jcb.140.4.935" @default.
- W2006393800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2141753" @default.
- W2006393800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9472044" @default.
- W2006393800 hasPublicationYear "1998" @default.
- W2006393800 type Work @default.
- W2006393800 sameAs 2006393800 @default.
- W2006393800 citedByCount "135" @default.
- W2006393800 countsByYear W20063938002012 @default.
- W2006393800 countsByYear W20063938002013 @default.
- W2006393800 countsByYear W20063938002014 @default.
- W2006393800 countsByYear W20063938002015 @default.
- W2006393800 countsByYear W20063938002016 @default.
- W2006393800 countsByYear W20063938002017 @default.