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• W2006397579 abstract "For a long time, telomeres have been considered to be transcriptionally silent. Very recently, a breaking finding from two groups demonstrated that telomere DNA is transcribed into telomeric repeat-containing RNA in mammalian cells (Azzalin, C. M.; Reichenbach, P.; Khoriauli, L.; Giulotto, E.; Lingner, J. Science 2007, 318, 798-801. Schoefter, S.; Blasco, M. A. Nat. Cell Biol. 2008, 10, 228-236). The telomeric RNA, a newly appeared player in telomere biology, may be a key component of telomere machinery. In the current study, we used a combination of NMR, circular dichroism (CD), matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOFMS), and gel electrophoresis to investigate the structural features of a human telomere RNA sequence. We demonstrated that human telomere RNA can form a parallel G-quadruplex structure in the presence of Na(+). Importantly, we found for the first time that the G-quadruplex forming telomere RNA protects itself from enzymatic digestion. These results provide valuable information to allow understanding of the structure and function of human telomeric RNA." @default.
• W2006397579 created "2016-06-24" @default.
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• W2006397579 date "2008-07-19" @default.
• W2006397579 modified "2023-10-02" @default.
• W2006397579 title "G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na⁺ Solution" @default.
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• W2006397579 doi "https://doi.org/10.1021/ja8031532" @default.
• W2006397579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18642813" @default.
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