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- W2006402788 abstract "Over 40 missense mutations in the human SCN1A sodium channel gene are linked to an epilepsy syndrome termed genetic epilepsy with febrile seizures plus (GEFS+). Inheritance of GEFS+ is dominant, but the underlying cellular mechanisms remain poorly understood. Here we report that knock-in of a GEFS+ SCN1A mutation (K1270T) into the Drosophila sodium channel gene, para , causes a semidominant temperature-induced seizure phenotype. Electrophysiological studies of GABAergic interneurons in the brains of adult GEFS+ flies reveal a novel cellular mechanism underlying heat-induced seizures: the deactivation threshold for persistent sodium currents reversibly shifts to a more negative voltage when the temperature is elevated. This leads to sustained depolarizations in GABAergic neurons and reduced inhibitory activity in the central nervous system. Furthermore, our data indicate a natural temperature-dependent shift in sodium current deactivation (exacerbated by mutation) may contribute to febrile seizures in GEFS+ and perhaps normal individuals." @default.
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- W2006402788 date "2012-10-10" @default.
- W2006402788 modified "2023-10-07" @default.
- W2006402788 title "A Knock-In Model of Human Epilepsy in<i>Drosophila</i>Reveals a Novel Cellular Mechanism Associated with Heat-Induced Seizure" @default.
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- W2006402788 doi "https://doi.org/10.1523/jneurosci.2932-12.2012" @default.
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