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- W2006403774 abstract "After intraperitoneal inoculation with Listeria monocytogenes, γδ T cells appear in the peritoneal cavity preceding the appearance of αβ T cells. Such γδ T cells predominantly express T-cell receptor (TCR)Vγ1/Vδ6, develop through an extrathymic pathway, and contribute to host defence against the bacteria. We have observed a gradual increase in γδ T cells in kidneys of mice after intrarenal inoculation with L. monocytogenes, which resulted in an unusually long-lasting local infection. In this study, we examined the characteristics and the roles of the γδ T cells induced in this model. It was found that these γδ T cells predominantly expressed TCRVγ6/Vδ1 with canonical junctional sequences identical to those expressed on fetal thymocytes. Although depletion of such γδ T cells in vivo did not affect the number of bacteria, it resulted in histologically exacerbated inflammation in the kidneys. These results indicate that a persistent infection with L. monocytogenes in kidneys induces a different kind of γδ T cell from that induced after intraperitoneal infection. The former expresses invariant fetal-type Vγ6/Vδ1+TCR and plays a regulatory role in resolution of inflammation." @default.
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- W2006403774 date "2001-01-01" @default.
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- W2006403774 title "Persistent infection with<i>Listeria monocytogenes</i>in the kidney induces anti-inflammatory invariant fetal-type γδ T cells" @default.
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- W2006403774 doi "https://doi.org/10.1046/j.1365-2567.2001.01149.x" @default.
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