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- W2006406228 abstract "Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from pathogen recognition receptors (PRRs) that recognize pathogenic nucleic acids. Moreover, IRF7 is a multifunctional transcription factor, underscored by the fact that it is associated with EBV latency, in which IRF7 is induced as well as activated by the EBV principal oncoprotein latent membrane protein-1 (LMP1). Aberrant production of type I IFNs is associated with many types of diseases such as cancers and autoimmune disorders. Thus, tight regulation of IRF7 expression and activity is imperative in dictating appropriate type I IFN production for normal IFN-mediated physiological functions. Posttranslational modifications have important roles in regulation of IRF7 activity, exemplified by phosphorylation, which is indicative of its activation. Furthermore, mounting evidence has shed light on the importance of regulatory ubiquitination in activation of IRF7. Albeit these exciting findings have been made in the past decade since its discovery, many questions related to IRF7 remain to be addressed." @default.
- W2006406228 created "2016-06-24" @default.
- W2006406228 creator A5050436106 @default.
- W2006406228 creator A5059365171 @default.
- W2006406228 creator A5075719027 @default.
- W2006406228 date "2011-04-14" @default.
- W2006406228 modified "2023-10-06" @default.
- W2006406228 title "IRF7: activation, regulation, modification and function" @default.
- W2006406228 cites W1487058632 @default.
- W2006406228 cites W1507472194 @default.
- W2006406228 cites W1534551308 @default.
- W2006406228 cites W1583341340 @default.
- W2006406228 cites W1605910291 @default.
- W2006406228 cites W1665408633 @default.
- W2006406228 cites W1738782024 @default.
- W2006406228 cites W1796893883 @default.
- W2006406228 cites W1860159973 @default.
- W2006406228 cites W1921320812 @default.
- W2006406228 cites W1951864429 @default.
- W2006406228 cites W1963967499 @default.
- W2006406228 cites W1964659850 @default.
- W2006406228 cites W1964664555 @default.
- W2006406228 cites W1966567943 @default.
- W2006406228 cites W1967007963 @default.
- W2006406228 cites W1968178474 @default.
- W2006406228 cites W1968458610 @default.
- W2006406228 cites W1969354039 @default.
- W2006406228 cites W1969430178 @default.
- W2006406228 cites W1970136020 @default.
- W2006406228 cites W1970199385 @default.
- W2006406228 cites W1973282958 @default.
- W2006406228 cites W1973425911 @default.
- W2006406228 cites W1973472843 @default.
- W2006406228 cites W1974817469 @default.
- W2006406228 cites W1976862171 @default.
- W2006406228 cites W1976891021 @default.
- W2006406228 cites W1978795609 @default.
- W2006406228 cites W1978990512 @default.
- W2006406228 cites W1980394089 @default.
- W2006406228 cites W1980652850 @default.
- W2006406228 cites W1981403111 @default.
- W2006406228 cites W1982120218 @default.
- W2006406228 cites W1985477675 @default.
- W2006406228 cites W1987038702 @default.
- W2006406228 cites W1987105457 @default.
- W2006406228 cites W1987334631 @default.
- W2006406228 cites W1987493797 @default.
- W2006406228 cites W1988278234 @default.
- W2006406228 cites W1988808478 @default.
- W2006406228 cites W1989643386 @default.
- W2006406228 cites W1989929798 @default.
- W2006406228 cites W1992057818 @default.
- W2006406228 cites W1993332077 @default.
- W2006406228 cites W1993347488 @default.
- W2006406228 cites W1994094364 @default.
- W2006406228 cites W1994786046 @default.
- W2006406228 cites W1994980446 @default.
- W2006406228 cites W1995150169 @default.
- W2006406228 cites W1997982156 @default.
- W2006406228 cites W1998282199 @default.
- W2006406228 cites W2000175632 @default.
- W2006406228 cites W2000267046 @default.
- W2006406228 cites W2001514368 @default.
- W2006406228 cites W2001653597 @default.
- W2006406228 cites W2002406704 @default.
- W2006406228 cites W2005375258 @default.
- W2006406228 cites W2005884645 @default.
- W2006406228 cites W2006265632 @default.
- W2006406228 cites W2006759162 @default.
- W2006406228 cites W2007893158 @default.
- W2006406228 cites W2008458519 @default.
- W2006406228 cites W2010160850 @default.
- W2006406228 cites W2010498205 @default.
- W2006406228 cites W2010609657 @default.
- W2006406228 cites W2011265690 @default.
- W2006406228 cites W2011529553 @default.
- W2006406228 cites W2011678998 @default.
- W2006406228 cites W2012451630 @default.
- W2006406228 cites W2014890686 @default.
- W2006406228 cites W2015784798 @default.
- W2006406228 cites W2017481656 @default.
- W2006406228 cites W2018828712 @default.
- W2006406228 cites W2020314417 @default.
- W2006406228 cites W2020464368 @default.
- W2006406228 cites W2021048400 @default.
- W2006406228 cites W2023501836 @default.
- W2006406228 cites W2023566832 @default.
- W2006406228 cites W2028545443 @default.
- W2006406228 cites W2028792773 @default.
- W2006406228 cites W2028994878 @default.
- W2006406228 cites W2029093937 @default.
- W2006406228 cites W2030618676 @default.
- W2006406228 cites W2030739472 @default.
- W2006406228 cites W2030748058 @default.
- W2006406228 cites W2031182394 @default.
- W2006406228 cites W2031355052 @default.
- W2006406228 cites W2031826040 @default.
- W2006406228 cites W2031913105 @default.