Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006408095> ?p ?o ?g. }
- W2006408095 abstract "Recent epidemiological evidence suggests that modifying lifestyle by increasing physical activity could be a non-pharmacological approach to improving symptoms and slowing disease progression in Alzheimer's disease and other tauopathies. Previous studies have shown that exercise reduces tau hyperphosphorylation, however, it is not known whether exercise reduces the accumulation of soluble or insoluble tau aggregates and neurofibrillary tangles, which are both neuropathological hallmarks of neurodegenerative tauopathy. In this study, 7-month old P301S tau transgenic mice were subjected to 12-weeks of forced treadmill exercise and evaluated for effects on motor function and tau pathology at 10 months of age.Exercise improved general locomotor and exploratory activity and resulted in significant reductions in full-length and hyperphosphorylated tau in the spinal cord and hippocampus as well as a reduction in sarkosyl-insoluble AT8-tau in the spinal cord. Exercise did not attenuate significant neuron loss in the hippocampus or cortex. Key proteins involved in autophagy-microtubule-associated protein 1A/1B light chain 3 and p62/sequestosome 1 -were also measured to assess whether autophagy is implicated in the exercised-induced reduction of aggregated tau protein. There were no significant effects of forced treadmill exercise on autophagy protein levels in P301S mice.Our results suggest that forced treadmill exercise differently affects the brain and spinal cord of aged P301S tau mice, with greater benefits observed in the spinal cord versus the brain. Our work adds to the growing body of evidence that exercise is beneficial in tauopathy, however these benefits may be more limited at later stages of disease." @default.
- W2006408095 created "2016-06-24" @default.
- W2006408095 creator A5001049709 @default.
- W2006408095 creator A5034410231 @default.
- W2006408095 creator A5064885955 @default.
- W2006408095 creator A5080933567 @default.
- W2006408095 date "2014-11-28" @default.
- W2006408095 modified "2023-10-18" @default.
- W2006408095 title "Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice" @default.
- W2006408095 cites W1508661542 @default.
- W2006408095 cites W1568808108 @default.
- W2006408095 cites W1800951710 @default.
- W2006408095 cites W1861299606 @default.
- W2006408095 cites W186368040 @default.
- W2006408095 cites W1963521777 @default.
- W2006408095 cites W1965205152 @default.
- W2006408095 cites W1965576196 @default.
- W2006408095 cites W1969129718 @default.
- W2006408095 cites W1970516662 @default.
- W2006408095 cites W1971390912 @default.
- W2006408095 cites W1972402714 @default.
- W2006408095 cites W1977493316 @default.
- W2006408095 cites W1979160568 @default.
- W2006408095 cites W1980768099 @default.
- W2006408095 cites W1981258222 @default.
- W2006408095 cites W1981782246 @default.
- W2006408095 cites W1982757333 @default.
- W2006408095 cites W1983102049 @default.
- W2006408095 cites W1986733770 @default.
- W2006408095 cites W1988044873 @default.
- W2006408095 cites W1989723790 @default.
- W2006408095 cites W1991189029 @default.
- W2006408095 cites W1992079632 @default.
- W2006408095 cites W1992973287 @default.
- W2006408095 cites W1994459030 @default.
- W2006408095 cites W1994470316 @default.
- W2006408095 cites W1994504660 @default.
- W2006408095 cites W1995609628 @default.
- W2006408095 cites W1995800438 @default.
- W2006408095 cites W1996484789 @default.
- W2006408095 cites W2001133644 @default.
- W2006408095 cites W2003109394 @default.
- W2006408095 cites W2007072722 @default.
- W2006408095 cites W2007818439 @default.
- W2006408095 cites W2009742165 @default.
- W2006408095 cites W2009870816 @default.
- W2006408095 cites W2011074122 @default.
- W2006408095 cites W2018947767 @default.
- W2006408095 cites W2027619670 @default.
- W2006408095 cites W2028028255 @default.
- W2006408095 cites W2029706844 @default.
- W2006408095 cites W2030667534 @default.
- W2006408095 cites W2030845247 @default.
- W2006408095 cites W2032233259 @default.
- W2006408095 cites W2033672635 @default.
- W2006408095 cites W2035123765 @default.
- W2006408095 cites W2036234078 @default.
- W2006408095 cites W2037653131 @default.
- W2006408095 cites W2038336612 @default.
- W2006408095 cites W2038552323 @default.
- W2006408095 cites W2040405257 @default.
- W2006408095 cites W2041988771 @default.
- W2006408095 cites W2047439821 @default.
- W2006408095 cites W2051197668 @default.
- W2006408095 cites W2051532765 @default.
- W2006408095 cites W2052171331 @default.
- W2006408095 cites W2053082937 @default.
- W2006408095 cites W2053298975 @default.
- W2006408095 cites W2054933404 @default.
- W2006408095 cites W2055147828 @default.
- W2006408095 cites W2057249855 @default.
- W2006408095 cites W2063049351 @default.
- W2006408095 cites W2063193894 @default.
- W2006408095 cites W2063994372 @default.
- W2006408095 cites W2066151668 @default.
- W2006408095 cites W2067587647 @default.
- W2006408095 cites W2069887356 @default.
- W2006408095 cites W2070835061 @default.
- W2006408095 cites W2071068165 @default.
- W2006408095 cites W2072677528 @default.
- W2006408095 cites W2075398676 @default.
- W2006408095 cites W2075721398 @default.
- W2006408095 cites W2077789090 @default.
- W2006408095 cites W2078163068 @default.
- W2006408095 cites W2079260094 @default.
- W2006408095 cites W2083095333 @default.
- W2006408095 cites W2083186327 @default.
- W2006408095 cites W2084871129 @default.
- W2006408095 cites W2086190042 @default.
- W2006408095 cites W2086765278 @default.
- W2006408095 cites W2089432935 @default.
- W2006408095 cites W2089936534 @default.
- W2006408095 cites W2091240085 @default.
- W2006408095 cites W2091829752 @default.
- W2006408095 cites W2092036232 @default.
- W2006408095 cites W2092889411 @default.
- W2006408095 cites W2095963715 @default.
- W2006408095 cites W2096481146 @default.
- W2006408095 cites W2096517300 @default.
- W2006408095 cites W2100084621 @default.