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• W2006410312 endingPage "154" @default.
• W2006410312 startingPage "141" @default.
• W2006410312 abstract "Lymphocytes are characterised by monoclonal expression of antigen receptors. This is achieved by silencing of one of two homologous antigen receptor alleles, a process known as allelic exclusion. This process is regulated both before and after V(D)J recombination, by a variety of mechanisms. These include nuclear localisation, changes in chromatin structure and histone modifications, non-coding sense and antisense RNA transcription, epigenetic alterations at the DNA level, feedback signalling from expressed alleles, locus contraction and decontraction, recruitment to heterochromatin. This review will focus on recent advances in the immunoglobulin heavy and kappa light chain loci. The current picture is of a complex, temporally ordered sequence of events, in which these loci share many contributory mechanisms, but clear and intriguing differences are emerging." @default.
• W2006410312 created "2016-06-24" @default.
• W2006410312 creator A5055754473 @default.
• W2006410312 date "2005-04-01" @default.
• W2006410312 modified "2023-09-26" @default.
• W2006410312 title "Immunoglobulin locus silencing and allelic exclusion" @default.
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